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RGS11 regulator of G protein signaling 11 [ Homo sapiens (human) ]

Gene ID: 8786, updated on 17-Jun-2019

Summary

Official Symbol
RGS11provided by HGNC
Official Full Name
regulator of G protein signaling 11provided by HGNC
Primary source
HGNC:HGNC:9993
See related
Ensembl:ENSG00000076344 MIM:603895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RS11
Summary
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]
Expression
Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues See more
Orthologs

Genomic context

See RGS11 in Genome Data Viewer
Location:
16p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (268301..275944, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (318300..325941, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene LUC7 like Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene family with sequence similarity 234 member A Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene protein disulfide isomerase family A member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of regulator of G-protein signaling 11 (RGS11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
    Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystem (from REACTOME)
    Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, organism-specific biosystemThe chaperonin complex TRiC/CCT is needed for the proper folding of all five G-protein beta subunits (Wells et al. 2006). TRiC/CCT cooperates with the phosducin-like protein PDCL (commonly known as P...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of G-protein signaling 11
Names
regulator of G-protein signalling 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286485.2NP_001273414.1  regulator of G-protein signaling 11 isoform 3

    See identical proteins and their annotated locations for NP_001273414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of a coding exon and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB016929, AF035153, CK299324, DC423811, Z69667
    Consensus CDS
    CCDS66884.1
    UniProtKB/Swiss-Prot
    O94810
    Related
    ENSP00000352778.5, ENST00000359740.6
    Conserved Domains (3) summary
    smart00224
    Location:212273
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:284409
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    cd04450
    Location:24107
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. NM_001286486.2NP_001273415.1  regulator of G-protein signaling 11 isoform 4

    See identical proteins and their annotated locations for NP_001273415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and lacks two alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AF035153, AK091701, CK299324, DC423811, Z69667
    UniProtKB/Swiss-Prot
    O94810
    Conserved Domains (2) summary
    smart00224
    Location:39100
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:111236
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
  3. NM_003834.3NP_003825.1  regulator of G-protein signaling 11 isoform 2

    See identical proteins and their annotated locations for NP_003825.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1. This results in translation initiation at a downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF035154, CK299324, DC423811, Z69667
    Consensus CDS
    CCDS10403.1
    UniProtKB/Swiss-Prot
    O94810
    Related
    ENSP00000319069.5, ENST00000316163.9
    Conserved Domains (3) summary
    smart00224
    Location:202263
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:274399
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    cd04450
    Location:390
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  4. NM_183337.3NP_899180.1  regulator of G-protein signaling 11 isoform 1

    See identical proteins and their annotated locations for NP_899180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF035153, CK299324, DC423811, Z69667
    Consensus CDS
    CCDS42088.1
    UniProtKB/Swiss-Prot
    O94810
    UniProtKB/TrEMBL
    Q4TT70
    Related
    ENSP00000380876.3, ENST00000397770.8
    Conserved Domains (3) summary
    smart00224
    Location:223284
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:295420
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    cd04450
    Location:24111
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    268301..275944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522719.2XP_011521021.1  regulator of G-protein signaling 11 isoform X1

    Conserved Domains (3) summary
    smart00224
    Location:255316
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:327452
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    cd04450
    Location:24106
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. XM_011522720.2XP_011521022.1  regulator of G-protein signaling 11 isoform X2

    Conserved Domains (3) summary
    smart00224
    Location:234295
    GGL; G protein gamma subunit-like motifs
    cd08740
    Location:306431
    RGS_RGS11; Regulator of G protein signaling (RGS) domain found in the RGS11 protein
    cd04450
    Location:385
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. XM_011522723.1XP_011521025.1  regulator of G-protein signaling 11 isoform X5

    See identical proteins and their annotated locations for XP_011521025.1

    UniProtKB/TrEMBL
    B7Z285
    Conserved Domains (1) summary
    cd04450
    Location:24111
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  4. XM_011522722.1XP_011521024.1  regulator of G-protein signaling 11 isoform X4

    Conserved Domains (1) summary
    cd04450
    Location:24106
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  5. XM_011522721.1XP_011521023.1  regulator of G-protein signaling 11 isoform X3

    Conserved Domains (1) summary
    cd04450
    Location:24106
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RNA

  1. XR_932957.2 RNA Sequence

    Related
    ENST00000168869.12
  2. XR_001752015.1 RNA Sequence

  3. XR_001752014.1 RNA Sequence

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