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PTH1R parathyroid hormone 1 receptor [ Bos taurus (domestic cattle) ]

Gene ID: 507783, updated on 18-Aug-2024

Summary

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Official Symbol
PTH1Rprovided by VGNC
Official Full Name
parathyroid hormone 1 receptorprovided by VGNC
Primary source
VGNC:VGNC:33514
See related
BGD:BT27113; Ensembl:ENSBTAG00000016948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PTHR1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (52598230..52623666, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene neurobeachin like 2 Neighboring gene coiled-coil domain containing 12 Neighboring gene myosin light chain 3 Neighboring gene serine protease 42

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of bovine parathyroid hormone/parathyroid hormone- related protein (PTH/PTHrP) receptor mRNA in the mammary gland of cows. Onda K, et al. J Vet Med Sci, 2006 Jun. PMID 16820722
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of the PTH/PTHrP receptor in dairy cows before and after parturition is reported.
    Title: Expression of bovine parathyroid hormone/parathyroid hormone- related protein (PTH/PTHrP) receptor mRNA in the mammary gland of cows.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC138946

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables parathyroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
parathyroid hormone/parathyroid hormone-related peptide receptor
Names
PTH/PTHr receptor
PTH/PTHrP type I receptor
PTH1 receptor
parathyroid hormone receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075332.1 → NP_001068800.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_001068800.1

    Status: PROVISIONAL

    Source sequence(s)
    BC116022
    UniProtKB/Swiss-Prot
    Q1LZF7
    UniProtKB/TrEMBL
    A0A3Q1N0Y5
    Related
    ENSBTAP00000022555.5, ENSBTAT00000022555.7
    Conserved Domains (2) summary
    pfam00002
    Location:184 → 454
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:105 → 173
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    52598230..52623666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223049.5 → XP_005223106.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

    See identical proteins and their annotated locations for XP_005223106.1

    UniProtKB/TrEMBL
    A0A3Q1N0Y5, F1N6Y3
    Related
    ENSBTAP00000058682.2, ENSBTAT00000070865.2
    Conserved Domains (2) summary
    pfam00002
    Location:184 → 454
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:105 → 173
    HRM; Hormone receptor domain

  2. XM_024982512.1 → XP_024838280.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MQC7, A0A3Q1N0Y5
    Related
    ENSBTAP00000073806.1, ENSBTAT00000068142.2
    Conserved Domains (2) summary
    pfam02793
    Location:162 → 230
    HRM; Hormone receptor domain
    cd15984
    Location:241 → 532
    7tmB1_PTH1R; parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  3. XM_024982514.2 → XP_024838282.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LI90
    Related
    ENSBTAP00000062510.2, ENSBTAT00000070571.2
    Conserved Domains (2) summary
    pfam02793
    Location:114 → 182
    HRM; Hormone receptor domain
    cd15984
    Location:193 → 484
    7tmB1_PTH1R; parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  4. XM_024982513.2 → XP_024838281.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MQC7, A0A3Q1N0Y5
    Conserved Domains (2) summary
    pfam02793
    Location:162 → 230
    HRM; Hormone receptor domain
    cd15984
    Location:241 → 532
    7tmB1_PTH1R; parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  5. XM_059879556.1 → XP_059735539.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

    UniProtKB/TrEMBL
    A0A3Q1N0Y5, F1N6Y3

  6. XM_059879555.1 → XP_059735538.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MQC7, A0A3Q1N0Y5

  7. XM_024982515.2 → XP_024838283.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X4

    UniProtKB/TrEMBL
    A0A3Q1N0Y5
    Conserved Domains (2) summary
    pfam02793
    Location:74 → 142
    HRM; Hormone receptor domain
    cd15984
    Location:153 → 444
    7tmB1_PTH1R; parathyroid hormone 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1LZF7.1 GenPept UniProtKB/Swiss-Prot:Q1LZF7

Gene LinkOut

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Molecular Biology Databases
Research Materials