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Pth1r parathyroid hormone 1 receptor [ Mus musculus (house mouse) ]

Gene ID: 19228, updated on 18-Sep-2018

Summary

Official Symbol
Pth1rprovided by MGI
Official Full Name
parathyroid hormone 1 receptorprovided by MGI
Primary source
MGI:MGI:97801
See related
Ensembl:ENSMUSG00000032492 Vega:OTTMUSG00000052494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPR; Pthr; Pthr1
Expression
Biased expression in kidney adult (RPKM 207.3), limb E14.5 (RPKM 43.7) and 4 other tissues See more
Orthologs

Genomic context

See Pth1r in Genome Data Viewer
Location:
9 F2; 9 60.56 cM
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (110722085..110747145, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110624589..110649649, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene neurobeachin-like 2 Neighboring gene microRNA 8107 Neighboring gene coiled-coil domain containing 12 Neighboring gene predicted gene, 35715 Neighboring gene predicted gene, 35775 Neighboring gene myosin, light polypeptide 3 Neighboring gene 60S ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
parathyroid hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
parathyroid hormone receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
parathyroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
parathyroid hormone receptor activity TAS
Traceable Author Statement
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
parathyroid hormone/parathyroid hormone-related peptide receptor
Names
PTH-related peptide receptor
PTH/PTHr receptor
PTH/PTHrP receptor
PTH/PTHrP type I receptor
PTH1 receptor
parathyroid hormone receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083935.1NP_001077404.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_001077404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC139378, AI607947, BC051981, CB192926
    Consensus CDS
    CCDS52940.1
    UniProtKB/Swiss-Prot
    P41593
    Related
    ENSMUSP00000132064.1, ENSMUST00000166716.7
    Conserved Domains (2) summary
    pfam00002
    Location:184455
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:105170
    HRM; Hormone receptor domain
  2. NM_001083936.1NP_001077405.1  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_001077405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AI607947, BB614354, BC051981
    Consensus CDS
    CCDS52940.1
    UniProtKB/Swiss-Prot
    P41593
    Related
    ENSMUSP00000006005.7, OTTMUSP00000070331, ENSMUST00000006005.11, OTTMUST00000131641
    Conserved Domains (2) summary
    pfam00002
    Location:184455
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:105170
    HRM; Hormone receptor domain
  3. NM_011199.2NP_035329.2  parathyroid hormone/parathyroid hormone-related peptide receptor precursor

    See identical proteins and their annotated locations for NP_035329.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC139378, AI607947, BC051981, BY005592
    Consensus CDS
    CCDS52940.1
    UniProtKB/Swiss-Prot
    P41593
    Related
    ENSMUSP00000143298.1, OTTMUSP00000070332, ENSMUST00000198865.4, OTTMUST00000131642
    Conserved Domains (2) summary
    pfam00002
    Location:184455
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:105170
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    110722085..110747145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511987.2XP_006512050.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X4

    Conserved Domains (2) summary
    pfam00002
    Location:200471
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:121186
    HRM; Hormone receptor domain
  2. XM_006511988.3XP_006512051.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X5

    Conserved Domains (2) summary
    pfam00002
    Location:178449
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:99164
    HRM; Hormone receptor domain
  3. XM_017313215.1XP_017168704.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X5

    Conserved Domains (2) summary
    pfam00002
    Location:178449
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:99164
    HRM; Hormone receptor domain
  4. XM_017313214.1XP_017168703.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X2

  5. XM_006511985.2XP_006512048.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X1

    Conserved Domains (3) summary
    pfam01543
    Location:51114
    HCV_capsid; Hepatitis C virus capsid protein
    pfam00002
    Location:326597
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:247312
    HRM; Hormone receptor domain
  6. XM_011242942.1XP_011241244.1  parathyroid hormone/parathyroid hormone-related peptide receptor isoform X3

    Conserved Domains (3) summary
    pfam01543
    Location:51114
    HCV_capsid; Hepatitis C virus capsid protein
    pfam00002
    Location:326597
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:247312
    HRM; Hormone receptor domain
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