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Sirt6 sirtuin 6 [ Mus musculus (house mouse) ]

Gene ID: 50721, updated on 22-May-2022

Summary

Official Symbol
Sirt6provided by MGI
Official Full Name
sirtuin 6provided by MGI
Primary source
MGI:MGI:1354161
See related
Ensembl:ENSMUSG00000034748 AllianceGenome:MGI:1354161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l6; AI043036; 2810449N18Rik
Summary
Enables several functions, including NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); and transcription corepressor activity. Involved in several processes, including cellular protein modification process; negative regulation of nucleobase-containing compound metabolic process; and positive regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 15.8), ovary adult (RPKM 15.8) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81457621..81463631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81621787..81627792, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (81084531..81090353, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transducin-like enhancer of split 2 Neighboring gene transducin-like enhancer of split 6 Neighboring gene zinc finger protein pseudogene Neighboring gene ankyrin repeat domain 24 Neighboring gene predicted gene 10778

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K56 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) TAS
Traceable Author Statement
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription elongation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel branching ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to chromatin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in post-embryonic cardiac muscle cell growth involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in subtelomeric heterochromatin assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, subtelomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
NAD-dependent deacetylase sirtuin-6
SIR2-like protein 6
regulatory protein SIR2 homolog 6
NP_001156902.1
NP_001365873.1
NP_001365874.1
NP_853617.1
XP_011241809.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163430.2NP_001156902.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    See identical proteins and their annotated locations for NP_001156902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the UTRs and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS48645.1
    UniProtKB/TrEMBL
    Q3UKP1
    Related
    ENSMUSP00000113953.2, ENSMUST00000119324.8
    Conserved Domains (1) summary
    cd01410
    Location:5217
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  2. NM_001378944.1NP_001365873.1  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC153919
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  3. NM_001378945.1NP_001365874.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC153919
    Conserved Domains (1) summary
    cd01410
    Location:5217
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
  4. NM_181586.4NP_853617.1  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    See identical proteins and their annotated locations for NP_853617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS24066.1
    UniProtKB/Swiss-Prot
    P59941
    Related
    ENSMUSP00000048971.9, ENSMUST00000042923.9
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RNA

  1. NR_166193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153919

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81457621..81463631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243507.4XP_011241809.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

    Conserved Domains (1) summary
    cl00195
    Location:101261
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...