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Sirt6 sirtuin 6 [ Mus musculus (house mouse) ]

Gene ID: 50721, updated on 12-Jul-2020

Summary

Official Symbol
Sirt6provided by MGI
Official Full Name
sirtuin 6provided by MGI
Primary source
MGI:MGI:1354161
See related
Ensembl:ENSMUSG00000034748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l6; AI043036; 2810449N18Rik
Expression
Ubiquitous expression in thymus adult (RPKM 15.8), ovary adult (RPKM 15.8) and 28 other tissues See more
Orthologs

Genomic context

See Sirt6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
108.20200622 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81621787..81627792, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (81084531..81090353, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene transducin-like enhancer of split 6 Neighboring gene predicted gene, 32024 Neighboring gene zinc finger protein pseudogene Neighboring gene ankyrin repeat domain 24 Neighboring gene predicted gene 10778

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent histone deacetylase activity (H3-K9 specific) TAS
Traceable Author Statement
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation blood vessel branching ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chromatin silencing at telomere ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomeric heterochromatin assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
post-embryonic cardiac muscle cell growth involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromosome, subtelomeric region ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
NAD-dependent deacetylase sirtuin-6
SIR2-like protein 6
regulatory protein SIR2 homolog 6
NP_001156902.1
NP_001365873.1
NP_001365874.1
NP_853617.1
XP_011241809.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163430.2NP_001156902.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    See identical proteins and their annotated locations for NP_001156902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the UTRs and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS48645.1
    UniProtKB/TrEMBL
    Q3UKP1
    Related
    ENSMUSP00000113953.1, ENSMUST00000119324.7
    Conserved Domains (1) summary
    cd01410
    Location:5217
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
  2. NM_001378944.1NP_001365873.1  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC153919
  3. NM_001378945.1NP_001365874.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC153919
  4. NM_181586.4NP_853617.1  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    See identical proteins and their annotated locations for NP_853617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC153919
    Consensus CDS
    CCDS24066.1
    UniProtKB/Swiss-Prot
    P59941
    Related
    ENSMUSP00000048971.8, ENSMUST00000042923.8
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

RNA

  1. NR_166193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153919

RefSeqs of Annotated Genomes: Mus musculus Updated Annotation Release 108.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    81621787..81627792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243507.3XP_011241809.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

    Conserved Domains (1) summary
    cl00195
    Location:101261
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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