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SIRT6 sirtuin 6 [ Homo sapiens (human) ]

Gene ID: 51548, updated on 28-Nov-2021

Summary

Official Symbol
SIRT6provided by HGNC
Official Full Name
sirtuin 6provided by HGNC
Primary source
HGNC:HGNC:14934
See related
Ensembl:ENSG00000077463 MIM:606211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L6
Summary
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in colon (RPKM 11.3), spleen (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See SIRT6 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4174109..4182563, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4174106..4182560, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6873 Neighboring gene cAMP responsive element binding protein 3 like 3 Neighboring gene ankyrin repeat domain 24 Neighboring gene Epstein-Barr virus induced 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD-dependent histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity TAS
Traceable Author Statement
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of blood vessel branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription factor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein destabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in subtelomeric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome, subtelomeric region IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-6
Names
SIR2-like protein 6
regulatory protein SIR2 homolog 6
sir2-related protein type 6
sirtuin type 6
NP_001180214.1
NP_001307987.1
NP_001307988.1
NP_001307989.1
NP_001307990.1
NP_001307991.1
NP_001307992.1
NP_001307993.1
NP_057623.2
XP_024307307.1
XP_024307308.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047153.1 RefSeqGene

    Range
    5037..13491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193285.3NP_001180214.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC006930, AC016586, BC028220, CN364177
    Consensus CDS
    CCDS54199.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000305310.5, ENST00000305232.10
    Conserved Domains (1) summary
    cl00195
    Location:45230
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_001321058.2NP_001307987.1  NAD-dependent protein deacetylase sirtuin-6 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC016586, AK293348, BC028220
    UniProtKB/Swiss-Prot
    Q8N6T7
    UniProtKB/TrEMBL
    B4DDV3
    Conserved Domains (1) summary
    cl00195
    Location:1185
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. NM_001321059.2NP_001307988.1  NAD-dependent protein deacetylase sirtuin-6 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BQ060703, CN364177
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000470215.1, ENST00000597896.5
    Conserved Domains (1) summary
    cl00195
    Location:45196
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. NM_001321060.2NP_001307989.1  NAD-dependent protein deacetylase sirtuin-6 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, CN364175, CN364177
    UniProtKB/Swiss-Prot
    Q8N6T7
    Conserved Domains (1) summary
    cl00195
    Location:45205
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. NM_001321061.2NP_001307990.1  NAD-dependent protein deacetylase sirtuin-6 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC016586, BC004218, BC028220, CN364177
    UniProtKB/Swiss-Prot
    Q8N6T7
    Conserved Domains (1) summary
    cl00195
    Location:1158
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  6. NM_001321062.2NP_001307991.1  NAD-dependent protein deacetylase sirtuin-6 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BP418952, CN364177
    UniProtKB/Swiss-Prot
    Q8N6T7
    Conserved Domains (1) summary
    cl00195
    Location:1122
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  7. NM_001321063.2NP_001307992.1  NAD-dependent protein deacetylase sirtuin-6 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK225567, BC028220, BE281103, CN364177
    Consensus CDS
    CCDS82276.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    UniProtKB/TrEMBL
    M0QXA0
    Related
    ENSP00000469001.1, ENST00000601488.5
    Conserved Domains (1) summary
    cl00195
    Location:45144
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  8. NM_001321064.2NP_001307993.1  NAD-dependent protein deacetylase sirtuin-6 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC006930, AK074810, AL559383, BC028220
    Consensus CDS
    CCDS82275.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    UniProtKB/TrEMBL
    M0R1N9
    Related
    ENSP00000472023.1, ENST00000594279.5
    Conserved Domains (1) summary
    cl00195
    Location:1133
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  9. NM_016539.4NP_057623.2  NAD-dependent protein deacetylase sirtuin-6 isoform 1

    See identical proteins and their annotated locations for NP_057623.2

    Status: REVIEWED

    Source sequence(s)
    AK074810, BC005026, CN364177
    Consensus CDS
    CCDS12122.1
    UniProtKB/Swiss-Prot
    Q8N6T7
    Related
    ENSP00000337332.1, ENST00000337491.7
    Conserved Domains (1) summary
    cd01410
    Location:45257
    SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4174109..4182563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451540.1XP_024307308.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

    Conserved Domains (1) summary
    cl00195
    Location:1133
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_024451539.1XP_024307307.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

    Conserved Domains (1) summary
    cl00195
    Location:42233
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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