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PAM peptidylglycine alpha-amidating monooxygenase [ Homo sapiens (human) ]

Gene ID: 5066, updated on 8-Dec-2018

Summary

Official Symbol
PAMprovided by HGNC
Official Full Name
peptidylglycine alpha-amidating monooxygenaseprovided by HGNC
Primary source
HGNC:HGNC:8596
See related
Ensembl:ENSG00000145730 MIM:170270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAL; PHM
Summary
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Expression
Broad expression in heart (RPKM 269.6), adrenal (RPKM 54.3) and 15 other tissues See more
Orthologs

Genomic context

See PAM in Genome Data Viewer
Location:
5q21.1
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (102754783..103031105)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (102201527..102366809)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 492 Neighboring gene long intergenic non-protein coding RNA 491 Neighboring gene VISTA enhancer hs1649 Neighboring gene uncharacterized LOC105379104 Neighboring gene uncharacterized LOC105379105 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidylamidoglycolate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidylamidoglycolate lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidylglycine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidylglycine monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
limb development IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
odontogenesis IEA
Inferred from Electronic Annotation
more info
 
ovulation cycle process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peptide amidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide amidation IDA
Inferred from Direct Assay
more info
PubMed 
protein amidation IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to copper ion IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to pH IEA
Inferred from Electronic Annotation
more info
 
toxin metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-glycine alpha-amidating monooxygenase
Names
pancreatic peptidylglycine alpha-amidating monooxygenase
peptidyl alpha-amidating enzyme
peptidyl-alpha-hydroxyglycine alpha-amidating lyase
peptidylamidoglycolate lyase
peptidylglycine 2-hydroxylase
peptidylglycine alpha-hydroxylating monooxygenase
NP_000910.2
NP_001170777.1
NP_001306872.1
NP_620121.1
NP_620176.1
NP_620177.1
XP_011541721.1
XP_016864984.1
XP_016864985.1
XP_016864986.1
XP_016864988.1
XP_016864989.1
XP_016864991.1
XP_016864993.1
XP_016864994.1
XP_016864996.1
XP_016864997.1
XP_016864998.1
XP_016865000.1
XP_024301834.1
XP_024301835.1
XP_024301836.1
XP_024301837.1
XP_024301838.1
XP_024301839.1
XP_024301840.1
XP_024301841.1
XP_024301842.1
XP_024301843.1
XP_024301844.1
XP_024301845.1
XP_024301846.1
XP_024301847.1
XP_024301848.1
XP_024301849.1
XP_024301850.1
XP_024301851.1
XP_024301852.1
XP_024301853.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029444.2 RefSeqGene

    Range
    116041..281323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000919.3NP_000910.2  peptidyl-glycine alpha-amidating monooxygenase isoform a precursor

    See identical proteins and their annotated locations for NP_000910.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 5. The encoded isoform (a) is longer than isoform e. This isoform (a) may undergo proteolytic processing similar to isoform e.
    Source sequence(s)
    AC010250, BI966687, DA240822, M37721
    Consensus CDS
    CCDS43348.1
    UniProtKB/Swiss-Prot
    P19021
    Related
    ENSP00000306100.7, ENST00000304400.11
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  2. NM_001177306.1NP_001170777.1  peptidyl-glycine alpha-amidating monooxygenase isoform e preproprotein

    See identical proteins and their annotated locations for NP_001170777.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform e.
    Source sequence(s)
    AB095007, AC010250, BI966687, DA240822
    Consensus CDS
    CCDS54885.1
    UniProtKB/Swiss-Prot
    P19021
    Related
    ENSP00000396493.3, ENST00000438793.7
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  3. NM_001319943.1NP_001306872.1  peptidyl-glycine alpha-amidating monooxygenase isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and contains an alternate in-frame exon in its central coding region compared to variant 5. The encoded isoform (f) is longer than isoform e and may undergo proteolytic processing similar to isoform e.
    Source sequence(s)
    AB095007, AC010250, BI966687, DA240822, DA406933, U19966
    UniProtKB/Swiss-Prot
    P19021
    UniProtKB/TrEMBL
    O43832
    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  4. NM_001364582.1NP_001351511.1  peptidyl-glycine alpha-amidating monooxygenase isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  5. NM_001364583.1NP_001351512.1  peptidyl-glycine alpha-amidating monooxygenase isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  6. NM_001364584.1NP_001351513.1  peptidyl-glycine alpha-amidating monooxygenase isoform i precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  7. NM_001364585.1NP_001351514.1  peptidyl-glycine alpha-amidating monooxygenase isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  8. NM_001364586.1NP_001351515.1  peptidyl-glycine alpha-amidating monooxygenase isoform k precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  9. NM_001364587.1NP_001351516.1  peptidyl-glycine alpha-amidating monooxygenase isoform l precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  10. NM_001364588.1NP_001351517.1  peptidyl-glycine alpha-amidating monooxygenase isoform m precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  11. NM_001364589.1NP_001351518.1  peptidyl-glycine alpha-amidating monooxygenase isoform n precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  12. NM_001364590.1NP_001351519.1  peptidyl-glycine alpha-amidating monooxygenase isoform o

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:424731
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:392
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:120266
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  13. NM_001364591.1NP_001351520.1  peptidyl-glycine alpha-amidating monooxygenase isoform p precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:411718
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  14. NM_001364592.1NP_001351521.1  peptidyl-glycine alpha-amidating monooxygenase isoform q precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:411718
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  15. NM_001364593.1NP_001351522.1  peptidyl-glycine alpha-amidating monooxygenase isoform r precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  16. NM_001364594.1NP_001351523.1  peptidyl-glycine alpha-amidating monooxygenase isoform s precursor

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC010250, AC113373
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  17. NM_138766.2NP_620121.1  peptidyl-glycine alpha-amidating monooxygenase isoform b precursor

    See identical proteins and their annotated locations for NP_620121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as PAM-15) lacks an alternate in-frame exon in the 3' coding region compared to variant 5. The encoded isoform (b) is shorter than isoform e. This isoform (b) may undergo proteolytic processing similar to isoform e.
    Source sequence(s)
    AC010250, BI966687, DA240822, S75038
    Consensus CDS
    CCDS4092.1
    UniProtKB/Swiss-Prot
    P19021
    Related
    ENSP00000403461.2, ENST00000455264.6
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  18. NM_138821.2NP_620176.1  peptidyl-glycine alpha-amidating monooxygenase isoform c precursor

    See identical proteins and their annotated locations for NP_620176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 5. The encoded isoform (c) is shorter than isoform e. This isoform (c) may undergo proteolytic processing similar to isoform e.
    Source sequence(s)
    AC010250, BI966687, BT007419, DA240822
    Consensus CDS
    CCDS4093.1
    UniProtKB/Swiss-Prot
    P19021
    Related
    ENSP00000314638.3, ENST00000348126.6
    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  19. NM_138822.2NP_620177.1  peptidyl-glycine alpha-amidating monooxygenase isoform d precursor

    See identical proteins and their annotated locations for NP_620177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region compared to variant 5. The encoded isoform (d) is shorter than isoform e. This isoform (d) may undergo proteolytic processing similar to isoform e.
    Source sequence(s)
    AC010250, AF010472, BI966687, DA240822
    Consensus CDS
    CCDS4094.1
    UniProtKB/Swiss-Prot
    P19021
    Related
    ENSP00000282992.3, ENST00000346918.6
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RNA

  1. NR_033440.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon in the 5' region and uses two alternate splice sites in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010250, AC113373, AK296521, BI966687, DA240822
  2. NR_157231.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008501, AC008779, AC113373

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    102754783..103031105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446066.1XP_024301834.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  2. XM_024446069.1XP_024301837.1  peptidyl-glycine alpha-amidating monooxygenase isoform X6

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  3. XM_017009495.2XP_016864984.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  4. XM_017009496.2XP_016864985.1  peptidyl-glycine alpha-amidating monooxygenase isoform X3

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  5. XM_017009502.2XP_016864991.1  peptidyl-glycine alpha-amidating monooxygenase isoform X10

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  6. XM_024446072.1XP_024301840.1  peptidyl-glycine alpha-amidating monooxygenase isoform X11

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  7. XM_024446075.1XP_024301843.1  peptidyl-glycine alpha-amidating monooxygenase isoform X14

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  8. XM_017009511.2XP_016865000.1  peptidyl-glycine alpha-amidating monooxygenase isoform X21

    Conserved Domains (3) summary
    cd14958
    Location:518795
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  9. XM_024446080.1XP_024301848.1  peptidyl-glycine alpha-amidating monooxygenase isoform X22

    Conserved Domains (3) summary
    cd14958
    Location:518795
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  10. XM_024446081.1XP_024301849.1  peptidyl-glycine alpha-amidating monooxygenase isoform X23

    Conserved Domains (3) summary
    cd14958
    Location:518795
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  11. XM_024446067.1XP_024301835.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  12. XM_024446068.1XP_024301836.1  peptidyl-glycine alpha-amidating monooxygenase isoform X5

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  13. XM_017009499.2XP_016864988.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  14. XM_017009500.2XP_016864989.1  peptidyl-glycine alpha-amidating monooxygenase isoform X8

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  15. XM_024446074.1XP_024301842.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  16. XM_024446076.1XP_024301844.1  peptidyl-glycine alpha-amidating monooxygenase isoform X15

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  17. XM_024446077.1XP_024301845.1  peptidyl-glycine alpha-amidating monooxygenase isoform X16

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  18. XM_024446078.1XP_024301846.1  peptidyl-glycine alpha-amidating monooxygenase isoform X17

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  19. XM_017009508.2XP_016864997.1  peptidyl-glycine alpha-amidating monooxygenase isoform X18

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  20. XM_024446082.1XP_024301850.1  peptidyl-glycine alpha-amidating monooxygenase isoform X24

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  21. XM_024446070.1XP_024301838.1  peptidyl-glycine alpha-amidating monooxygenase isoform X9

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  22. XM_024446073.1XP_024301841.1  peptidyl-glycine alpha-amidating monooxygenase isoform X12

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  23. XM_024446079.1XP_024301847.1  peptidyl-glycine alpha-amidating monooxygenase isoform X20

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  24. XM_024446083.1XP_024301851.1  peptidyl-glycine alpha-amidating monooxygenase isoform X25

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  25. XM_024446084.1XP_024301852.1  peptidyl-glycine alpha-amidating monooxygenase isoform X26

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  26. XM_017009509.2XP_016864998.1  peptidyl-glycine alpha-amidating monooxygenase isoform X19

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  27. XM_011543419.3XP_011541721.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

    See identical proteins and their annotated locations for XP_011541721.1

    Conserved Domains (3) summary
    cd14958
    Location:518825
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  28. XM_017009497.2XP_016864986.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

    UniProtKB/Swiss-Prot
    P19021
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  29. XM_017009505.2XP_016864994.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

    UniProtKB/Swiss-Prot
    P19021
    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  30. XM_017009507.2XP_016864996.1  peptidyl-glycine alpha-amidating monooxygenase isoform X16

    Conserved Domains (3) summary
    cd14958
    Location:393700
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  31. XM_024446071.1XP_024301839.1  peptidyl-glycine alpha-amidating monooxygenase isoform X9

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  32. XM_017009504.2XP_016864993.1  peptidyl-glycine alpha-amidating monooxygenase isoform X12

    Conserved Domains (3) summary
    cd14958
    Location:500807
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:59168
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:196342
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  33. XM_024446085.1XP_024301853.1  peptidyl-glycine alpha-amidating monooxygenase isoform X27

    Conserved Domains (3) summary
    cd14958
    Location:442749
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:392
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:120266
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RNA

  1. XR_001742084.2 RNA Sequence

  2. XR_002956157.1 RNA Sequence

  3. XR_002956158.1 RNA Sequence

  4. XR_001742086.2 RNA Sequence

    Related
    ENST00000345721.6
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