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PALM paralemmin [ Homo sapiens (human) ]

Gene ID: 5064, updated on 18-Sep-2018

Summary

Official Symbol
PALMprovided by HGNC
Official Full Name
paralemminprovided by HGNC
Primary source
HGNC:HGNC:8594
See related
Ensembl:ENSG00000099864 MIM:608134; Vega:OTTHUMG00000181785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 28.7), brain (RPKM 22.8) and 18 other tissues See more
Orthologs

Genomic context

See PALM in Genome Data Viewer
Location:
19p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (708953..748330)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (708953..748330)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene follistatin like 3 Neighboring gene serine protease 57 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene mitotic spindle positioning Neighboring gene uncharacterized LOC101928450

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D3 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
synapse maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
intrinsic component of the cytoplasmic side of the plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040134.1NP_001035224.1  paralemmin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC032449, BM667870, BU508077, CN344023, DA521203
    Consensus CDS
    CCDS32858.1
    UniProtKB/Swiss-Prot
    O75781
    UniProtKB/TrEMBL
    A0A024R207
    Related
    ENSP00000264560.7, OTTHUMP00000267457, ENST00000264560.11, OTTHUMT00000457591
    Conserved Domains (3) summary
    cd14458
    Location:1053
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:71343
    Paralemmin; Paralemmin
    cl07405
    Location:1053
    DP_DD; Dimerization domain of DP
  2. NM_002579.2NP_002570.2  paralemmin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC032449, BM667870, BP199809, BU508077
    Consensus CDS
    CCDS32857.1
    UniProtKB/Swiss-Prot
    O75781
    UniProtKB/TrEMBL
    A0A024R1Y6
    Related
    ENSP00000341911.4, OTTHUMP00000267458, ENST00000338448.9, OTTHUMT00000457592
    Conserved Domains (3) summary
    cd14458
    Location:1053
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:71387
    Paralemmin; Paralemmin
    cl07405
    Location:1053
    DP_DD; Dimerization domain of DP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    708953..748330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026850.2XP_016882339.1  paralemmin-1 isoform X3

  2. XM_005259565.4XP_005259622.1  paralemmin-1 isoform X1

    Conserved Domains (3) summary
    cd14458
    Location:1255
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:73389
    Paralemmin; Paralemmin
    cl07405
    Location:1255
    DP_DD; Dimerization domain of DP
  3. XM_005259566.4XP_005259623.1  paralemmin-1 isoform X2

    Conserved Domains (3) summary
    cd14458
    Location:952
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:70386
    Paralemmin; Paralemmin
    cl07405
    Location:952
    DP_DD; Dimerization domain of DP
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