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Palm paralemmin [ Mus musculus (house mouse) ]

Gene ID: 18483, updated on 24-Sep-2025
Official Symbol
Palmprovided by MGI
Official Full Name
paralemminprovided by MGI
Primary source
MGI:MGI:1261814
See related
Ensembl:ENSMUSG00000035863 AllianceGenome:MGI:1261814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables D3 dopamine receptor binding activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of dendritic spine development; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and regulation of cell shape. Located in several cellular components, including filopodium; neuron spine; and postsynaptic density. Is expressed in several structures, including eye; liver; nasal epithelium; nervous system; and renal cortex. Orthologous to human PALM (paralemmin). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 57.4), adrenal adult (RPKM 54.7) and 23 other tissues See more
Orthologs
human all
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See Palm in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79629406..79656749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79793572..79820915)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E899 Neighboring gene ring finger protein 126 Neighboring gene STARR-positive B cell enhancer ABC_E719 Neighboring gene follistatin-like 3 Neighboring gene serine protease 57 Neighboring gene predicted gene, 40713 Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79314980-79315089 Neighboring gene polypyrimidine tract binding protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology. Kalebic N, et al. Cell Stem Cell, 2019 Apr 4. PMID 30905618
  2. Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis. Albrecht I, et al. Angiogenesis, 2013 Oct. PMID 23709172
  3. Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton. Macarrón-Palacios V, et al. Sci Adv, 2025 Mar 7. PMID 40053592, Free PMC Article
  4. PALML, a novel paralemmin-related gene mapping on human chromosome 1p21. Andreu N, et al. Gene, 2001 Oct 31. PMID 11707320
  5. Palm is expressed in both developing and adult mouse lens and retina. Castellini M, et al. BMC Ophthalmol, 2005 Jun 21. PMID 15969763, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paralemmin-1 is expressed in normal and tumor-derived lymphatic endothelial cells. It represses cell migration and delays the formation of tube-like lymphatic structures by modulating cell adhesion, filopodia formation and plasma membrane blebbing.
    Title: Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis.
  2. Expression of Palm in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
    Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
  3. report that palmitoylation-deficient (Palm(-/-)) mice carrying two Cys to Thr and Ser mutations in the opsin gene displayed profound light-induced retinal degeneration that first involved rod and then cone cells.
    Title: Palmitoylation stabilizes unliganded rod opsin.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D3 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to electrical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium membrane IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
paralemmin-1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161747.1 → NP_001155219.1  paralemmin-1 isoform 2

    See identical proteins and their annotated locations for NP_001155219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC151828, AK082163, AK162411
    Consensus CDS
    CCDS48621.1
    UniProtKB/TrEMBL
    Q542N8, Q91WF5
    Related
    ENSMUSP00000101018.3, ENSMUST00000105379.3
    Conserved Domains (3) summary
    cd14458
    Location:10 → 53
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:71 → 339
    Paralemmin; Paralemmin
    cl07405
    Location:10 → 53
    DP_DD; Dimerization domain of DP

  2. NM_001428706.1 → NP_001415635.1  paralemmin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124407
    UniProtKB/TrEMBL
    A0A1W2P831

  3. NM_001428707.1 → NP_001415636.1  paralemmin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124407
    UniProtKB/TrEMBL
    A0A1W2P879

  4. NM_023128.4 → NP_075617.3  paralemmin-1 isoform 1

    See identical proteins and their annotated locations for NP_075617.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC151828, AK037044, AK082163
    Consensus CDS
    CCDS23991.1
    UniProtKB/Swiss-Prot
    Q9Z0P3, Q9Z0P4
    UniProtKB/TrEMBL
    Q8CB16
    Related
    ENSMUSP00000040596.7, ENSMUST00000046945.13
    Conserved Domains (3) summary
    cd14458
    Location:10 → 53
    DP_DD; coiled coil [structural motif]
    pfam03285
    Location:71 → 383
    Paralemmin; Paralemmin
    cl07405
    Location:10 → 53
    DP_DD; Dimerization domain of DP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79629406..79656749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313830.2 → XP_017169319.1  paralemmin-1 isoform X1

    UniProtKB/TrEMBL
    Q6ZQE7
    Conserved Domains (1) summary
    pfam03285
    Location:2 → 314
    Paralemmin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0P4.1 GenPept UniProtKB/Swiss-Prot:Q9Z0P4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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