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IL20 interleukin 20 [ Homo sapiens (human) ]

Gene ID: 50604, updated on 1-Jun-2020

Summary

Official Symbol
IL20provided by HGNC
Official Full Name
interleukin 20provided by HGNC
Primary source
HGNC:HGNC:6002
See related
Ensembl:ENSG00000162891 MIM:605619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-20; IL10D; ZCYTO10
Summary
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL20 in Genome Data Viewer
Location:
1q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206865247..206869223)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207038699..207042568)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 10 Neighboring gene interleukin 19 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 24 Neighboring gene Fc fragment of IgM receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC96907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-20 receptor binding TAS
Traceable Author Statement
more info
PubMed 
interleukin-22 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-20
Names
cytokine Zcyto10
four alpha helix cytokine

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018724.3NP_061194.2  interleukin-20 precursor

    See identical proteins and their annotated locations for NP_061194.2

    Status: REVIEWED

    Source sequence(s)
    AF224266, AY358320, BC069311
    Consensus CDS
    CCDS1470.1
    UniProtKB/Swiss-Prot
    Q9NYY1
    Related
    ENSP00000356063.3, ENST00000367096.7
    Conserved Domains (1) summary
    cl02501
    Location:39173
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    206865247..206869223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273152.3XP_005273209.1  interleukin-20 isoform X1

    See identical proteins and their annotated locations for XP_005273209.1

    Conserved Domains (1) summary
    cl02501
    Location:124258
    IL10; Interleukin 10
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