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IL20 interleukin 20 [ Homo sapiens (human) ]

Gene ID: 50604, updated on 2-Nov-2024

Summary

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Official Symbol
IL20provided by HGNC
Official Full Name
interleukin 20provided by HGNC
Primary source
HGNC:HGNC:6002
See related
Ensembl:ENSG00000162891 MIM:605619; AllianceGenome:HGNC:6002
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-20; IL10D; ZCYTO10
Summary
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See IL20 in Genome Data Viewer
Location:
1q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206863565..206869223)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206127873..206133530)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207036910..207042568)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene interleukin 10 Neighboring gene interleukin 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene interleukin 24 Neighboring gene Fc mu receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis. Šenolt L, et al. Cytokine, 2017 Sep. PMID 28662439
  2. Decreased interleukin-20 level in patients with systemic sclerosis: are they related with angiogenesis? Aydoğdu E, et al. Clin Rheumatol, 2013 Nov. PMID 23812620
  3. IL-20 may contribute to the pathogenesis of human intervertebral disc herniation. Huang KY, et al. Spine (Phila Pa 1976), 2008 Sep 1. PMID 18758357
  4. Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis. Kudo H, et al. Arthritis Rheumatol, 2014 Jun. PMID 24470401, Free PMC Article
  5. Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin. Bech R, et al. Exp Dermatol, 2014 May. PMID 24628979

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of interleukin-20 on periodontal tissue destruction in individuals with periodontitis.
    Title: The effect of interleukin-20 on periodontal tissue destruction in individuals with periodontitis.
  2. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
    Title: IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
  3. IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
    Title: IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
  4. Overexpression of interleukin-20 correlates with favourable prognosis in diffuse large B-cell lymphoma.
    Title: Overexpression of interleukin-20 correlates with favourable prognosis in diffuse large B-cell lymphoma.
  5. gamma-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro.
    Title: γ-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro.
  6. Interleukin-20 is involved in dry eye disease and is a potential therapeutic target.
    Title: Interleukin-20 is involved in dry eye disease and is a potential therapeutic target.
  7. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
    Title: IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
  8. Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction.
    Title: Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction.
  9. IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
    Title: IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
  10. The expression of interleukin 20 increases in plasma and aortic tissues from patients with acute aortic dissection.
    Title: The expression of interleukin 20 increases in plasma and aortic tissues from patients with acute aortic dissection.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC96907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-20 receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-22 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epidermal cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of keratinocyte differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-20
Names
cytokine Zcyto10
four alpha helix cytokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385165.1 → NP_001372094.1  interleukin-20 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC098935
    Consensus CDS
    CCDS91155.1
    Related
    ENSP00000375796.2, ENST00000391930.3

  2. NM_001385166.1 → NP_001372095.1  interleukin-20 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC098935
    Consensus CDS
    CCDS1470.1
    UniProtKB/Swiss-Prot
    Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
    UniProtKB/TrEMBL
    A0A7R8C4W0
    Conserved Domains (1) summary
    cl02501
    Location:39 → 173
    IL10; Interleukin 10

  3. NM_001385167.1 → NP_001372096.1  interleukin-20 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC098935
    Consensus CDS
    CCDS1470.1
    UniProtKB/Swiss-Prot
    Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
    UniProtKB/TrEMBL
    A0A7R8C4W0
    Conserved Domains (1) summary
    cl02501
    Location:39 → 173
    IL10; Interleukin 10

  4. NM_018724.4 → NP_061194.2  interleukin-20 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061194.2

    Status: REVIEWED

    Source sequence(s)
    AC098935
    Consensus CDS
    CCDS1470.1
    UniProtKB/Swiss-Prot
    Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
    UniProtKB/TrEMBL
    A0A7R8C4W0
    Related
    ENSP00000356065.1, ENST00000367098.6
    Conserved Domains (1) summary
    cl02501
    Location:39 → 173
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206863565..206869223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206127873..206133530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYY1.2 GenPept UniProtKB/Swiss-Prot:Q9NYY1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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