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ATP5F1B ATP synthase F1 subunit beta [ Homo sapiens (human) ]

Gene ID: 506, updated on 4-Nov-2018

Summary

Official Symbol
ATP5F1Bprovided by HGNC
Official Full Name
ATP synthase F1 subunit betaprovided by HGNC
Primary source
HGNC:HGNC:830
See related
Ensembl:ENSG00000110955 MIM:102910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5B; ATPMB; ATPSB; HEL-S-271
Summary
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues See more
Orthologs

Genomic context

See ATP5F1B in Genome Data Viewer
Location:
12q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (56638175..56646068, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57031959..57039852, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene bromodomain adjacent to zinc finger domain 2A Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene RNA, 7SL, cytoplasmic 809, pseudogene Neighboring gene prostaglandin E synthase 3 Neighboring gene nascent polypeptide associated complex subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) in Jurkat cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ATP synthase beta subunit (ATP5B) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
MHC class I protein binding IDA
Inferred from Direct Assay
more info
PubMed 
angiostatin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
proton-transporting ATPase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase, catalytic core NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP synthase subunit beta, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
epididymis secretory protein Li 271
mitochondrial ATP synthase beta subunit
mitochondrial ATP synthetase, beta subunit
NP_001677.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001686.3NP_001677.2  ATP synthase subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001677.2

    Status: REVIEWED

    Source sequence(s)
    BC016512, BI561028
    Consensus CDS
    CCDS8924.1
    UniProtKB/Swiss-Prot
    P06576
    UniProtKB/TrEMBL
    V9HW31
    Related
    ENSP00000262030.3, ENST00000262030.7
    Conserved Domains (1) summary
    PRK09280
    Location:58524
    PRK09280; F0F1 ATP synthase subunit beta; Validated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    56638175..56646068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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