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SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

Gene ID: 5055, updated on 23-Dec-2018

Summary

Official Symbol
SERPINB2provided by HGNC
Official Full Name
serpin family B member 2provided by HGNC
Primary source
HGNC:HGNC:8584
See related
Ensembl:ENSG00000197632 MIM:173390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAI; PAI2; PAI-2; PLANH2; HsT1201
Expression
Biased expression in esophagus (RPKM 112.4), skin (RPKM 35.4) and 2 other tissues See more
Orthologs

Genomic context

See SERPINB2 in Genome Data Viewer
Location:
18q21.33-q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (63887705..63903890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61554939..61571124)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene serpin family B member 11 (gene/pseudogene) Neighboring gene serpin family B member 7 Neighboring gene serpin family B member 10 Neighboring gene uncharacterized LOC105372165 Neighboring gene histocompatibility minor serpin domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human B cells PubMed
env HIV-1 infection and HIV-1 gp120 treatment of human peripheral blood mononuclear cells result in induction of SerpinB2 and this induction enhances transcription from the HIV-1 LTR PubMed
Tat tat HIV-1 Tat upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human primary T cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of serpin peptidase inhibitor, clade B2 (SERPINB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
    Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
fibrinolysis TAS
Traceable Author Statement
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
plasminogen activator inhibitor 2
Names
monocyte Arg-serpin
placental plasminogen activator inhibitor
plasminogen activator inhibitor, type II (arginine-serpin)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serpin B2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
urokinase inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143818.1NP_001137290.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_001137290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, CD366374, DA543366, DQ656059
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120
    Related
    ENSP00000401645.1, ENST00000457692.5
    Conserved Domains (1) summary
    cd02058
    Location:4415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...
  2. NM_002575.3NP_002566.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_002566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, BC012609, CD366374
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120
    Related
    ENSP00000299502.4, ENST00000299502.8
    Conserved Domains (1) summary
    cd02058
    Location:4415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    63887705..63903890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451192.1XP_024306960.1  plasminogen activator inhibitor 2 isoform X1

    Conserved Domains (1) summary
    cd02058
    Location:4415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...
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