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Ero1a endoplasmic reticulum oxidoreductase 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 50527, updated on 13-Apr-2024

Summary

Official Symbol
Ero1aprovided by MGI
Official Full Name
endoplasmic reticulum oxidoreductase 1 alphaprovided by MGI
Primary source
MGI:MGI:1354385
See related
Ensembl:ENSMUSG00000021831 AllianceGenome:MGI:1354385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ero1l; ERO1-L
Summary
This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in placenta adult (RPKM 26.9), liver E18 (RPKM 11.5) and 26 other tissues See more
Orthologs
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Genomic context

Location:
14 C1; 14 22.86 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45520544..45556029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45283087..45318572, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E95 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene G protein-coupled receptor 137C Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene glucosamine-phosphate N-acetyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol oxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within L-ascorbic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell redox homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein folding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein folding ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein maturation by protein folding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi lumen ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ERO1-like protein alpha
Names
ERO1-L-alpha
ERO1-like
endoplasmic oxidoreductin-1-like protein
endoplasmic reticulum oxidation 1
endoplasmic reticulum oxidoreductase alpha
endoplasmic reticulum oxidoreductin-1-like protein
oxidoreductin-1-L-alpha
NP_056589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015774.3NP_056589.1  ERO1-like protein alpha precursor

    See identical proteins and their annotated locations for NP_056589.1

    Status: REVIEWED

    Source sequence(s)
    AC154575, AK009667, AK142595, BP753202, CJ215857
    Consensus CDS
    CCDS36893.1
    UniProtKB/Swiss-Prot
    Q8R180, Q9CV47, Q9QY03
    UniProtKB/TrEMBL
    Q4FJZ3, Q4FK57
    Related
    ENSMUSP00000022378.8, ENSMUST00000022378.9
    Conserved Domains (1) summary
    pfam04137
    Location:60451
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45520544..45556029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)