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ERO1A endoplasmic reticulum oxidoreductase 1 alpha [ Homo sapiens (human) ]

Gene ID: 30001, updated on 16-May-2020

Summary

Official Symbol
ERO1Aprovided by HGNC
Official Full Name
endoplasmic reticulum oxidoreductase 1 alphaprovided by HGNC
Primary source
HGNC:HGNC:13280
See related
Ensembl:ENSG00000197930 MIM:615435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERO1L; ERO1-L; ERO1LA; Ero1alpha; ERO1-alpha; ERO1-L-alpha
Expression
Broad expression in esophagus (RPKM 69.5), placenta (RPKM 19.1) and 21 other tissues See more
Orthologs

Genomic context

See ERO1A in Genome Data Viewer
Location:
14q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52639915..52695750, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53108605..53162419, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137C Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene serine/threonine/tyrosine interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as a reductase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
animal organ senescence IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
Inferred from Electronic Annotation
more info
 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein folding in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation by protein folding IEA
Inferred from Electronic Annotation
more info
 
release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
response to temperature stimulus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
ERO1-like protein alpha
Names
endoplasmic oxidoreductin-1-like protein
endoplasmic reticulum oxidoreductase alpha
oxidoreductin-1-L-alpha
NP_055399.1
XP_011534986.1
XP_024305322.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382464.1NP_001369393.1  ERO1-like protein alpha isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  2. NM_001382465.1NP_001369394.1  ERO1-like protein alpha isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  3. NM_001382466.1NP_001369395.1  ERO1-like protein alpha isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  4. NM_001382467.1NP_001369396.1  ERO1-like protein alpha isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  5. NM_001382468.1NP_001369397.1  ERO1-like protein alpha isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  6. NM_001382469.1NP_001369398.1  ERO1-like protein alpha isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  7. NM_001382470.1NP_001369399.1  ERO1-like protein alpha isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  8. NM_001382471.1NP_001369400.1  ERO1-like protein alpha isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  9. NM_001382472.1NP_001369401.1  ERO1-like protein alpha isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  10. NM_001382473.1NP_001369402.1  ERO1-like protein alpha isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  11. NM_001382474.1NP_001369403.1  ERO1-like protein alpha isoform 12 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  12. NM_001382475.1NP_001369404.1  ERO1-like protein alpha isoform 13 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  13. NM_001382476.1NP_001369405.1  ERO1-like protein alpha isoform 14 precursor

    Status: VALIDATED

    Source sequence(s)
    AL133453
  14. NM_014584.3NP_055399.1  ERO1-like protein alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_055399.1

    Status: VALIDATED

    Source sequence(s)
    AL133453, BC012941
    Consensus CDS
    CCDS9709.1
    UniProtKB/Swiss-Prot
    Q96HE7
    Related
    ENSP00000379042.3, ENST00000395686.8
    Conserved Domains (1) summary
    pfam04137
    Location:60455
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52639915..52695750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449554.1XP_024305322.1  ERO1-like protein alpha isoform X1

    Conserved Domains (1) summary
    pfam04137
    Location:60484
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
  2. XM_011536684.2XP_011534986.1  ERO1-like protein alpha isoform X2

    Conserved Domains (1) summary
    pfam04137
    Location:60451
    ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
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