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CHST11 carbohydrate sulfotransferase 11 [ Homo sapiens (human) ]

Gene ID: 50515, updated on 11-Jun-2025
Official Symbol
CHST11provided by HGNC
Official Full Name
carbohydrate sulfotransferase 11provided by HGNC
Primary source
HGNC:HGNC:17422
See related
Ensembl:ENSG00000171310 MIM:610128; AllianceGenome:HGNC:17422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4ST; C4ST1; OCBMD; C4ST-1; HSA269537
Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in appendix (RPKM 8.6), brain (RPKM 8.5) and 23 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See CHST11 in Genome Data Viewer
Location:
12q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104456948..104762014)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104418595..104723625)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104850726..105155792)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369949 Neighboring gene MPRA-validated peak1927 silencer Neighboring gene uncharacterized LOC124903003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6910 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:104808107-104809018 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104846113-104846615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104876710-104877210 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104885786-104885989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6920 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6921 Neighboring gene Sharpr-MPRA regulatory region 14866 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:104920569-104921159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104949096-104949598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:104950760-104951594 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997281-104997908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104997909-104998535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104998957-104999544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:104999545-105000132 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:105017531-105018268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105026139-105026640 Neighboring gene microRNA 3922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105065189-105065793 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:105081721-105081916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6931 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102028-105102832 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105102833-105103637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:105114284-105114912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105116877-105117495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105136527-105137148 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:105144840-105145417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6936 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24027 Neighboring gene Sharpr-MPRA regulatory region 12146 Neighboring gene solute carrier family 41 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6937 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24038 Neighboring gene Sharpr-MPRA regulatory region 3023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4800 Neighboring gene keratin 18 pseudogene 20

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Osteochondrodysplasia, brachydactyly, and overlapping malformed digits
MedGen: C4748496 OMIM: 618167 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of DSM-IV cannabis dependence.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ41682, DKFZp667A035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin 4-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 4-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chondroitin 4-sulfotransferase activity TAS
Traceable Author Statement
more info
 
enables dermatan 4-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chondrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in chondroitin sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chondroitin sulfate proteoglycan biosynthetic process TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within chondroitin sulfate proteoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within developmental growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within polysaccharide localization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
carbohydrate sulfotransferase 11
Names
C4S-1
IgH/CHST11 fusion
carbohydrate (chondroitin 4) sulfotransferase 11
chondroitin 4-O-sulfotransferase 1
NP_001167453.1
NP_060883.1
XP_047284870.1
XP_047284871.1
XP_054228123.1
XP_054228124.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029810.2 RefSeqGene

    Range
    5035..310101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173982.2NP_001167453.1  carbohydrate sulfotransferase 11 isoform 2

    See identical proteins and their annotated locations for NP_001167453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at the 5' terminal exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment near the N-terminus compared to isoform 1.
    Source sequence(s)
    AC073917, AJ289134, DA853534
    Consensus CDS
    CCDS55878.1
    UniProtKB/Swiss-Prot
    Q9NPF2
    Related
    ENSP00000450004.1, ENST00000549260.5
    Conserved Domains (1) summary
    pfam03567
    Location:108338
    Sulfotransfer_2; Sulfotransferase family
  2. NM_018413.6NP_060883.1  carbohydrate sulfotransferase 11 isoform 1

    See identical proteins and their annotated locations for NP_060883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073917, AK290923, DA853534
    Consensus CDS
    CCDS9099.1
    UniProtKB/Swiss-Prot
    A8K4F8, Q9NPF2, Q9NXY6, Q9NY36
    Related
    ENSP00000305725.5, ENST00000303694.6
    Conserved Domains (1) summary
    pfam03567
    Location:113343
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    104456948..104762014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428914.1XP_047284870.1  carbohydrate sulfotransferase 11 isoform X1

  2. XM_047428915.1XP_047284871.1  carbohydrate sulfotransferase 11 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    104418595..104723625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372148.1XP_054228123.1  carbohydrate sulfotransferase 11 isoform X1

  2. XM_054372149.1XP_054228124.1  carbohydrate sulfotransferase 11 isoform X1