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Chst11 carbohydrate sulfotransferase 11 [ Mus musculus (house mouse) ]

Gene ID: 58250, updated on 16-Apr-2024

Summary

Official Symbol
Chst11provided by MGI
Official Full Name
carbohydrate sulfotransferase 11provided by MGI
Primary source
MGI:MGI:1927166
See related
Ensembl:ENSMUSG00000034612 AllianceGenome:MGI:1927166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C4s; C4ST; C4ST1; C4ST-1; 1110020P09Rik
Summary
Enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Acts upstream of or within several processes, including chondroitin sulfate biosynthetic process; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; heart; and skeletal system. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 37.7), adrenal adult (RPKM 14.0) and 20 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 40.66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82820274..83031738)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82984440..83195904)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10633 Neighboring gene predicted gene, 33781 Neighboring gene predicted gene 4799 Neighboring gene STARR-seq mESC enhancer starr_27385 Neighboring gene STARR-seq mESC enhancer starr_27387 Neighboring gene RIKEN cDNA 1700025N21 gene Neighboring gene predicted gene, 53595 Neighboring gene solute carrier family 41, member 2 Neighboring gene STARR-seq mESC enhancer starr_27388 Neighboring gene STARR-positive B cell enhancer ABC_E2331 Neighboring gene STARR-seq mESC enhancer starr_27389 Neighboring gene predicted gene, 40722 Neighboring gene predicted gene, 40723

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosamine 4-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chondroitin 4-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chondroitin sulfate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within polysaccharide localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbohydrate sulfotransferase 11
Names
C4S-1
chondroitin 4
chondroitin 4-O-sulfotransferase 1
chondroitin 4-sulfotransferase 1
NP_067414.2
XP_006513971.1
XP_006513972.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429269.1NP_001416198.1  carbohydrate sulfotransferase 11

    Status: VALIDATED

    Source sequence(s)
    AC102114, AC155938, AC159149
  2. NM_021439.4NP_067414.2  carbohydrate sulfotransferase 11

    See identical proteins and their annotated locations for NP_067414.2

    Status: VALIDATED

    Source sequence(s)
    AC102114, AC155938, AC159149
    Consensus CDS
    CCDS24074.1
    UniProtKB/Swiss-Prot
    Q9JJS2, Q9JME2
    UniProtKB/TrEMBL
    B9EHC3
    Related
    ENSMUSP00000045349.8, ENSMUST00000040110.8
    Conserved Domains (1) summary
    pfam03567
    Location:113343
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    82820274..83031738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513909.4XP_006513972.1  carbohydrate sulfotransferase 11 isoform X2

    UniProtKB/TrEMBL
    B7ZMT9
    Conserved Domains (1) summary
    pfam03567
    Location:108338
    Sulfotransfer_2; Sulfotransferase family
  2. XM_006513908.5XP_006513971.1  carbohydrate sulfotransferase 11 isoform X1

    Conserved Domains (1) summary
    pfam03567
    Location:112342
    Sulfotransfer_2; Sulfotransferase family