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PODXL2 podocalyxin like 2 [ Homo sapiens (human) ]

Gene ID: 50512, updated on 1-Jun-2020

Summary

Official Symbol
PODXL2provided by HGNC
Official Full Name
podocalyxin like 2provided by HGNC
Primary source
HGNC:HGNC:17936
See related
Ensembl:ENSG00000114631 MIM:616627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EG; PODLX2
Summary
This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]
Expression
Broad expression in brain (RPKM 27.2), testis (RPKM 16.2) and 16 other tissues See more
Orthologs

Genomic context

See PODXL2 in Genome Data Viewer
Location:
3q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (127629185..127672802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127348002..127391653)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene microRNA 7976 Neighboring gene uncharacterized LOC107986126 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene monoglyceride lipase Neighboring gene uncharacterized LOC107986127 Neighboring gene MGLL intron CAGE-defined high expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycosaminoglycan binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
podocalyxin-like protein 2
Names
endoglycan

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015720.4NP_056535.1  podocalyxin-like protein 2 precursor

    See identical proteins and their annotated locations for NP_056535.1

    Status: REVIEWED

    Source sequence(s)
    AL524055, BC019330, BC052585
    Consensus CDS
    CCDS3044.1
    UniProtKB/Swiss-Prot
    Q9NZ53
    Related
    ENSP00000345359.6, ENST00000342480.7
    Conserved Domains (1) summary
    pfam06365
    Location:393604
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    127629185..127672802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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