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Podxl2 podocalyxin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 319655, updated on 2-Nov-2024

Summary

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Official Symbol
Podxl2provided by MGI
Official Full Name
podocalyxin-like 2provided by MGI
Primary source
MGI:MGI:2442488
See related
Ensembl:ENSMUSG00000033152 AllianceGenome:MGI:2442488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PODLX2; D130074J02Rik
Summary
Predicted to be involved in leukocyte tethering or rolling. Predicted to be located in membrane. Is expressed in genitourinary system; gut; nervous system; respiratory tract; and sensory organ. Orthologous to human PODXL2 (podocalyxin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 137.0), CNS E18 (RPKM 133.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Podxl2 in Genome Data Viewer
Location:
6 D1; 6 39.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (88819539..88852063, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (88842557..88875046, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26588 Neighboring gene monoglyceride lipase Neighboring gene STARR-positive B cell enhancer ABC_E10390 Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene predicted gene 15612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88836578-88836779 Neighboring gene STARR-positive B cell enhancer ABC_E2794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:88852049-88852232 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene transmembrane protein, adipocyte asscociated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons. Hsia HE, et al. FASEB J, 2021 Sep. PMID 34390512
  2. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Doyonnas R, et al. Blood, 2005 Jun 1. PMID 15701716
  3. Role of CD34 family members in lumen formation in the developing kidney. Yang Z, et al. Dev Biol, 2016 Oct 1. PMID 27542690, Free PMC Article
  4. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
podocalyxin-like protein 2
Names
endoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347327.2 → NP_001334256.1  podocalyxin-like protein 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC153923
    Consensus CDS
    CCDS85093.1
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    D3YW47
    Related
    ENSMUSP00000117954.3, ENSMUST00000145944.3

  2. NM_001364575.2 → NP_001351504.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC153923
    Consensus CDS
    CCDS20340.1
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Related
    ENSMUSP00000058985.5, ENSMUST00000061262.11
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  3. NM_001379217.1 → NP_001366146.1  podocalyxin-like protein 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:265 → 347
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:392 → 609
    CD34_antigen; CD34/Podocalyxin family

  4. NM_001379218.1 → NP_001366147.1  podocalyxin-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 545
    CD34_antigen; CD34/Podocalyxin family

  5. NM_001379219.1 → NP_001366148.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, and 7-10, encodes isoform 2.
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  6. NM_001379220.1 → NP_001366149.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-10, encodes isoform 2.
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  7. NM_001379221.1 → NP_001366150.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, 9, and isoform 210, encodes isoform 2.
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  8. NM_001379222.1 → NP_001366151.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10, encodes isoform 2.
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  9. NM_001379223.1 → NP_001366152.1  podocalyxin-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, and 6-9, encodes isoform 2.
    Source sequence(s)
    AC153923
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

  10. NM_176973.5 → NP_795947.3  podocalyxin-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_795947.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 6-10 all encode the same isoform (2).
    Source sequence(s)
    AC153923
    Consensus CDS
    CCDS20340.1
    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    UniProtKB/TrEMBL
    G3X9D3
    Related
    ENSMUSP00000040417.6, ENSMUST00000038409.12
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 538
    CD34_antigen; CD34/Podocalyxin family

RNA

  1. NR_166540.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153923

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    88819539..88852063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166218.1 → XP_036022111.1  podocalyxin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:348 → 430
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:475 → 692
    CD34_antigen; CD34/Podocalyxin family

  2. XM_011241375.3 → XP_011239677.1  podocalyxin-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011239677.1

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 545
    CD34_antigen; CD34/Podocalyxin family

  3. XM_030255448.2 → XP_030111308.1  podocalyxin-like protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 545
    CD34_antigen; CD34/Podocalyxin family

  4. XM_030255447.2 → XP_030111307.1  podocalyxin-like protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 545
    CD34_antigen; CD34/Podocalyxin family

  5. XM_030255445.1 → XP_030111305.1  podocalyxin-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:274 → 356
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:401 → 618
    CD34_antigen; CD34/Podocalyxin family

  6. XM_011241376.2 → XP_011239678.1  podocalyxin-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011239678.1

    UniProtKB/Swiss-Prot
    Q8CAE9, Q8CFW3
    Conserved Domains (2) summary
    PRK14959
    Location:201 → 283
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    pfam06365
    Location:328 → 545
    CD34_antigen; CD34/Podocalyxin family

RNA

  1. XR_004942963.1 RNA Sequence

  2. XR_004942964.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAE9.2 GenPept UniProtKB/Swiss-Prot:Q8CAE9

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