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NOX3 NADPH oxidase 3 [ Homo sapiens (human) ]

Gene ID: 50508, updated on 5-Aug-2022


Official Symbol
NOX3provided by HGNC
Official Full Name
NADPH oxidase 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000074771 MIM:607105; AllianceGenome:HGNC:7890
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOX-2; GP91-3
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
Low expression observed in reference dataset See more
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Genomic context

See NOX3 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (155395368..155455839, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (156597411..156657886, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (155716502..155776973, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 3 pseudogene Neighboring gene TIAM Rac1 associated GEF 2 Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene uncharacterized LOC105378068 Neighboring gene RNA, U7 small nuclear 152 pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
Nef nef NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells PubMed
Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed
tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
involved_in detection of gravity IEA
Inferred from Electronic Annotation
more info
involved_in otolith development IEA
Inferred from Electronic Annotation
more info
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
involved_in temperature homeostasis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
NADPH oxidase 3
NADPH oxidase catalytic subunit-like 3
gp91phox homolog 3
mitogenic oxidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_011995.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015718.3NP_056533.1  NADPH oxidase 3

    See identical proteins and their annotated locations for NP_056533.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    Q9HBJ9, Q9HBY0
    ENSP00000159060.2, ENST00000159060.3
    Conserved Domains (2) summary
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    155395368..155455839 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    156597411..156657886 complement
    GenBank, FASTA, Sequence Viewer (Graphics)