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PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Homo sapiens (human) ]

Gene ID: 5048, updated on 6-Sep-2017
Official Symbol
PAFAH1B1provided by HGNC
Official Full Name
platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by HGNC
Primary source
HGNC:HGNC:8574
See related
Ensembl:ENSG00000007168 MIM:601545; Vega:OTTHUMG00000177574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS; LIS1; LIS2; MDCR; NudF; PAFAH
Summary
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009]
Orthologs
Location:
17p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (2593210..2685617)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2496923..2588909)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 33, pseudogene Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 9 Neighboring gene sterile alpha motif domain containing 11 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 608, pseudogene Neighboring gene uncharacterized LOC105371490 Neighboring gene microRNA 6776 Neighboring gene clustered mitochondria homolog

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Lissencephaly 1 Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-04-19)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-04-19)

ClinGen Genome Curation PagePubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Inhibition of PP2A by LIS1 increases Tat mediated HIV-1 transcription PubMed
tat HIV-1 Tat interacts with LIS1 in vitro and in vivo, and this interaction might contribute to the effect of Tat on microtubule formation PubMed

Go to the HIV-1, Human Interaction Database

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Ether lipid metabolism, organism-specific biosystem (from KEGG)
    Ether lipid metabolism, organism-specific biosystem
    Ether lipid metabolism
  • Ether lipid metabolism, conserved biosystem (from KEGG)
    Ether lipid metabolism, conserved biosystem
    Ether lipid metabolism
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
    Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
    Lissencephaly gene (LIS1) in neuronal migration and development
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynactin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
phospholipase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
acrosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
ameboidal-type cell migration IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell development IEA
Inferred from Electronic Annotation
more info
 
brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
corpus callosum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cortical microtubule organization IEA
Inferred from Electronic Annotation
more info
 
establishment of centrosome localization IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of planar polarity of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
layer formation in cerebral cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
maintenance of centrosome location IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule cytoskeleton organization involved in establishment of planar polarity IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nuclear envelope disassembly IEA
Inferred from Electronic Annotation
more info
 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
 
osteoclast development IEA
Inferred from Electronic Annotation
more info
 
platelet activating factor metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
protein secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
retrograde axonal transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
sister chromatid cohesion TAS
Traceable Author Statement
more info
 
stem cell division IEA
Inferred from Electronic Annotation
more info
 
transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
central region of growth cone IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
stereocilium IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha
Names
lissencephaly 1 protein
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)
platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
NP_000421.1
XP_011522203.1
XP_011522204.1
XP_011522205.1
XP_016880188.1
XP_016880189.1
XP_016880190.1
XP_016880191.1
XP_016880192.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009799.1 RefSeqGene

    Range
    5001..96987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000430.3NP_000421.1  platelet-activating factor acetylhydrolase IB subunit alpha

    See identical proteins and their annotated locations for NP_000421.1

    Status: REVIEWED

    Source sequence(s)
    AC005696, AC015799
    Consensus CDS
    CCDS32528.1
    UniProtKB/Swiss-Prot
    P43034
    Related
    ENSP00000380378.4, OTTHUMP00000257094, ENST00000397195.9, OTTHUMT00000437797
    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:935
    LisH; LisH

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    2593210..2685617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024701.1XP_016880190.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X3

    UniProtKB/Swiss-Prot
    P43034
    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:935
    LisH; LisH
  2. XM_011523901.1XP_011522203.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011522203.1

    Conserved Domains (4) summary
    COG2319
    Location:115428
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:122426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:3053
    LisH; LisH
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]
  3. XM_017024702.1XP_016880191.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X4

  4. XM_017024703.1XP_016880192.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

  5. XM_017024700.1XP_016880189.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X3

    UniProtKB/Swiss-Prot
    P43034
    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:935
    LisH; LisH
  6. XM_011523902.2XP_011522204.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011522204.1

    Conserved Domains (4) summary
    COG2319
    Location:115428
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:122426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:3053
    LisH; LisH
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]
  7. XM_017024699.1XP_016880188.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X3

    UniProtKB/Swiss-Prot
    P43034
    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:935
    LisH; LisH
  8. XM_011523903.2XP_011522205.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_011522205.1

    Conserved Domains (4) summary
    COG2319
    Location:115428
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:122426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:3053
    LisH; LisH
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    2505702..2597647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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