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ORM2 orosomucoid 2 [ Homo sapiens (human) ]

Gene ID: 5005, updated on 23-Nov-2021

Summary

Official Symbol
ORM2provided by HGNC
Official Full Name
orosomucoid 2provided by HGNC
Primary source
HGNC:HGNC:8499
See related
Ensembl:ENSG00000228278 MIM:138610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGP2; AGP-B; AGP-B'
Summary
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 2828.2) See more
Orthologs
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Genomic context

See ORM2 in Genome Data Viewer
Location:
9q32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (114329869..114333251)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117092149..117095531)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376224 Neighboring gene Sharpr-MPRA regulatory region 10745 Neighboring gene orosomucoid 1 Neighboring gene AT-hook transcription factor Neighboring gene whirlin Neighboring gene small EDRK-rich factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM) PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of orosomucoid 2 (ORM2) expression as compared to untreated control PubMed
env Recombinant precursor gp160 (rgp160) or surface unit gp120 (rgp120) of HIV-1 and alpha 1-acid glycoprotein (AGP) show a specific low-affinity binding via N-linked glycans PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
alpha-1-acid glycoprotein 2
Names
AGP 2
OMD 2
alpha-1-acid glycoprotein, type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000608.4NP_000599.1  alpha-1-acid glycoprotein 2 precursor

    See identical proteins and their annotated locations for NP_000599.1

    Status: VALIDATED

    Source sequence(s)
    AL356796
    Consensus CDS
    CCDS6804.1
    UniProtKB/Swiss-Prot
    P19652
    Related
    ENSP00000394936.2, ENST00000431067.4
    Conserved Domains (1) summary
    pfam00061
    Location:40180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    114329869..114333251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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