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ORC5 origin recognition complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 5001, updated on 9-Feb-2020

Summary

Official Symbol
ORC5provided by HGNC
Official Full Name
origin recognition complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:8491
See related
Ensembl:ENSG00000164815 MIM:602331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC5L; ORC5P; ORC5T; PPP1R117
Summary
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues See more
Orthologs

Genomic context

See ORC5 in Genome Data Viewer
Location:
7q22.1-q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (104126341..104208047, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (103766788..103848495, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375435 Neighboring gene reelin Neighboring gene CRISPRi-validated cis-regulatory element chr7.3907 Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene uncharacterized LOC105375436 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromosome, telomeric region HDA PubMed 
nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 5
Names
protein phosphatase 1, regulatory subunit 117

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029899.1 RefSeqGene

    Range
    5035..86708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002553.4NP_002544.1  origin recognition complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_002544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007393, AK223361, BC023652
    Consensus CDS
    CCDS5734.1
    UniProtKB/Swiss-Prot
    O43913
    UniProtKB/TrEMBL
    A4D0P7, Q53FC8
    Related
    ENSP00000297431.4, ENST00000297431.9
    Conserved Domains (2) summary
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177431
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
  2. NM_181747.3NP_859531.1  origin recognition complex subunit 5 isoform 2

    See identical proteins and their annotated locations for NP_859531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exon, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC007393, AF081459, AK223361
    Consensus CDS
    CCDS47681.1
    UniProtKB/Swiss-Prot
    O43913
    UniProtKB/TrEMBL
    Q53FC8
    Related
    ENSP00000395747.2, ENST00000447452.6
    Conserved Domains (2) summary
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177290
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    104126341..104208047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516273.3XP_011514575.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (3) summary
    COG1474
    Location:11191
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177228
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RNA

  1. XR_001744792.2 RNA Sequence

    Related
    ENST00000422497.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001197292.1: Suppressed sequence

    Description
    NM_001197292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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