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Orc5 origin recognition complex, subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 26429, updated on 2-Nov-2024

Summary

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Official Symbol
Orc5provided by MGI
Official Full Name
origin recognition complex, subunit 5provided by MGI
Primary source
MGI:MGI:1347044
See related
Ensembl:ENSMUSG00000029012 AllianceGenome:MGI:1347044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc5l; MmORC5
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 8.3), liver E14.5 (RPKM 7.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Orc5 in Genome Data Viewer
Location:
5 A3; 5 10.07 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22691478..22755358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (22486480..22550338, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene reelin Neighboring gene predicted gene, 54324 Neighboring gene STARR-seq mESC enhancer starr_12584 Neighboring gene predicted gene, 42223 Neighboring gene predicted gene, 25459 Neighboring gene STARR-seq mESC enhancer starr_12585 Neighboring gene STARR-seq mESC enhancer starr_12586 Neighboring gene STARR-seq mESC enhancer starr_12587 Neighboring gene RIKEN cDNA 6030443J06 gene Neighboring gene STARR-seq mESC enhancer starr_12588 Neighboring gene STARR-seq mESC enhancer starr_12589 Neighboring gene ribosomal protein L22 like 1 pseudogene Neighboring gene predicted gene, 22887 Neighboring gene predicted gene, 42225 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer J, et al. Chromosoma, 1999 Aug. PMID 10460412
  2. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article
  3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 5
Names
origin recognition complex, subunit 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429001.1 → NP_001415930.1  origin recognition complex subunit 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121548

  2. NM_001429002.1 → NP_001415931.1  origin recognition complex subunit 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121548

  3. NM_001429003.1 → NP_001415932.1  origin recognition complex subunit 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121548

  4. NM_011959.4 → NP_036089.1  origin recognition complex subunit 5 isoform 1

    See identical proteins and their annotated locations for NP_036089.1

    Status: VALIDATED

    Source sequence(s)
    AC121548
    Consensus CDS
    CCDS19110.1
    UniProtKB/Swiss-Prot
    Q3TMI6, Q9WUV0
    Related
    ENSMUSP00000030872.6, ENSMUST00000030872.12
    Conserved Domains (3) summary
    COG1474
    Location:11 → 191
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:8 → 155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177 → 431
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    22691478..22755358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535716.5 → XP_006535779.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (2) summary
    pfam13191
    Location:1 → 62
    AAA_16; AAA ATPase domain
    pfam14630
    Location:84 → 338
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

  2. XM_036165143.1 → XP_036021036.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (2) summary
    pfam13191
    Location:1 → 62
    AAA_16; AAA ATPase domain
    pfam14630
    Location:84 → 338
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUV0.1 GenPept UniProtKB/Swiss-Prot:Q9WUV0

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