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Orc5 origin recognition complex, subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 26429, updated on 26-Sep-2022

Summary

Official Symbol
Orc5provided by MGI
Official Full Name
origin recognition complex, subunit 5provided by MGI
Primary source
MGI:MGI:1347044
See related
Ensembl:ENSMUSG00000029012 AllianceGenome:MGI:1347044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc5l; MmORC5
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 8.3), liver E14.5 (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See Orc5 in Genome Data Viewer
Location:
5; 5 A3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22691478..22755358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (22486480..22550338, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene reelin Neighboring gene predicted gene, 54324 Neighboring gene predicted gene, 42223 Neighboring gene predicted gene, 25459 Neighboring gene RIKEN cDNA 6030443J06 gene Neighboring gene ribosomal protein L22 like 1 pseudogene Neighboring gene predicted gene, 22887 Neighboring gene predicted gene, 42225 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
origin recognition complex subunit 5
Names
origin recognition complex, subunit 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011959.3NP_036089.1  origin recognition complex subunit 5

    See identical proteins and their annotated locations for NP_036089.1

    Status: VALIDATED

    Source sequence(s)
    AC121548
    Consensus CDS
    CCDS19110.1
    UniProtKB/Swiss-Prot
    Q3TMI6, Q9WUV0
    Related
    ENSMUSP00000030872.6, ENSMUST00000030872.12
    Conserved Domains (3) summary
    COG1474
    Location:11191
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:8155
    AAA_16; AAA ATPase domain
    pfam14630
    Location:177431
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    22691478..22755358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535716.5XP_006535779.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (2) summary
    pfam13191
    Location:162
    AAA_16; AAA ATPase domain
    pfam14630
    Location:84338
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
  2. XM_036165143.1XP_036021036.1  origin recognition complex subunit 5 isoform X1

    Conserved Domains (2) summary
    pfam13191
    Location:162
    AAA_16; AAA ATPase domain
    pfam14630
    Location:84338
    ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus