U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ORC4 origin recognition complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 5000, updated on 9-Jun-2024

Summary

Official Symbol
ORC4provided by HGNC
Official Full Name
origin recognition complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:8490
See related
Ensembl:ENSG00000115947 MIM:603056; AllianceGenome:HGNC:8490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORC4L; ORC4P
Summary
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in brain (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ORC4 in Genome Data Viewer
Location:
2q23.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (147930396..148021551, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (148380848..148472005, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (148687965..148779120, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 14 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:148600948-148601698 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11997 Neighboring gene RNA, U6 small nuclear 1275, pseudogene Neighboring gene activin A receptor type 2A Neighboring gene uncharacterized LOC105373674 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:148765513-148766712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:148777951-148778548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16614 Neighboring gene uncharacterized LOC105373673 Neighboring gene NANOG hESC enhancer GRCh37_chr2:148795224-148795725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16615 Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:148946661-148947364 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:149016781-149017980 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meier-Gorlin syndrome 2
MedGen: C3151097 OMIM: 613800 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ46668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in polar body extrusion after meiotic divisions IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome, telomeric region HDA PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear origin of replication recognition complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
origin recognition complex subunit 4
Names
origin recognition complex, subunit 4 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028252.1 RefSeqGene

    Range
    5868..96209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190879.3NP_001177808.1  origin recognition complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_001177808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC009480, BC014847, BX423253, DC302315, DC399282
    Consensus CDS
    CCDS2187.1
    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Related
    ENSP00000441953.1, ENST00000535373.5
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  2. NM_001190881.3NP_001177810.1  origin recognition complex subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001177810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons in the 5' region, which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC009480, AK295721, BP277082
    Consensus CDS
    CCDS54404.1
    UniProtKB/TrEMBL
    Q96B14
    Related
    ENSP00000441502.1, ENST00000536575.5
    Conserved Domains (2) summary
    COG1474
    Location:2142
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:144331
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  3. NM_001190882.3NP_001177811.1  origin recognition complex subunit 4 isoform 3

    See identical proteins and their annotated locations for NP_001177811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two consecutive exons in the 5' region, which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC009480, AK298862, BC005388
    Consensus CDS
    CCDS54405.1
    UniProtKB/TrEMBL
    Q96B14
    Related
    ENSP00000438326.1, ENST00000540442.5
    Conserved Domains (3) summary
    COG1474
    Location:4152
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:154331
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    cl21455
    Location:50139
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001374270.1NP_001361199.1  origin recognition complex subunit 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009480, AC019226
    Consensus CDS
    CCDS2187.1
    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  5. NM_001374272.1NP_001361201.1  origin recognition complex subunit 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009480, AC019226
    Consensus CDS
    CCDS54404.1
    UniProtKB/TrEMBL
    Q96B14
    Conserved Domains (2) summary
    COG1474
    Location:2142
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:144331
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  6. NM_002552.5NP_002543.2  origin recognition complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_002543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate segment in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC009480, AK291989, AK298862, DC317404
    Consensus CDS
    CCDS2187.1
    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  7. NM_181741.4NP_859525.1  origin recognition complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_859525.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC009480, BC014847, DA227202
    Consensus CDS
    CCDS2187.1
    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Related
    ENSP00000376597.5, ENST00000392857.10
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  8. NM_181742.4NP_859526.1  origin recognition complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_859526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC009480, BC016177, DC365653
    Consensus CDS
    CCDS2187.1
    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Related
    ENSP00000264169.2, ENST00000264169.6
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    147930396..148021551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511255.3XP_011509557.1  origin recognition complex subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_011509557.1

    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
    Conserved Domains (2) summary
    COG1474
    Location:43226
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:228415
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
  2. XM_047444573.1XP_047300529.1  origin recognition complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    B7Z2M4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    148380848..148472005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342311.1XP_054198286.1  origin recognition complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    B7Z3D0, B7Z5F1, D3DP86, F5H069, O43929, Q96C42
    UniProtKB/TrEMBL
    A8K7H4
  2. XM_054342312.1XP_054198287.1  origin recognition complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    B7Z2M4