U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ncoa7 nuclear receptor coactivator 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498995, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Ncoa7provided by RGD
Official Full Name
nuclear receptor coactivator 7provided by RGD
Primary source
RGD:1566426
See related
EnsemblRapid:ENSRNOG00000014004 AllianceGenome:RGD:1566426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566426
Summary
Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and response to oxidative stress. Predicted to act upstream of or within negative regulation of cellular response to oxidative stress; negative regulation of oxidative stress-induced neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be active in nucleus. Orthologous to human NCOA7 (nuclear receptor coactivator 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 261.8), Brain (RPKM 105.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (28674614..28835891)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (26856228..27016950)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (29225727..29386642)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hes-related family bHLH transcription factor with YRPW motif 2 Neighboring gene transfer RNA glutamic acid (anticodon CUC) 1 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene tRNA methyltransferase 11 homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ERAP140, a conserved tissue-specific nuclear receptor coactivator. Shao W, et al. Mol Cell Biol, 2002 May. PMID 11971969, Free PMC Article
  2. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. Finelli MJ, et al. J Biol Chem, 2016 Feb 5. PMID 26668325, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear receptor coactivator 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432412.1 → NP_001419341.1  nuclear receptor coactivator 7 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  2. NM_001432413.1 → NP_001419342.1  nuclear receptor coactivator 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001432414.1 → NP_001419343.1  nuclear receptor coactivator 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001432415.1 → NP_001419344.1  nuclear receptor coactivator 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    28674614..28835891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276554.1 → XP_063132624.1  nuclear receptor coactivator 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5XVX5, F1LWN1

  2. XM_063276558.1 → XP_063132628.1  nuclear receptor coactivator 7 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0R1

  3. XM_063276541.1 → XP_063132611.1  nuclear receptor coactivator 7 isoform X1

    UniProtKB/TrEMBL
    F1LWN1

  4. XM_039099278.2 → XP_038955206.1  nuclear receptor coactivator 7 isoform X1

    UniProtKB/TrEMBL
    F1LWN1
    Conserved Domains (2) summary
    smart00584
    Location:815 → 977
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:149 → 191
    LysM; LysM domain

  5. XM_039099281.2 → XP_038955209.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0R1
    Related
    ENSRNOP00000077233.2, ENSRNOT00000097027.2
    Conserved Domains (2) summary
    smart00584
    Location:804 → 966
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:149 → 191
    LysM; LysM domain

  6. XM_006227758.5 → XP_006227820.1  nuclear receptor coactivator 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5XVX5, F1LWN1
    Related
    ENSRNOP00000099439.1, ENSRNOT00000150078.1
    Conserved Domains (2) summary
    smart00584
    Location:783 → 945
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:117 → 159
    LysM; LysM domain

  7. XM_063276557.1 → XP_063132627.1  nuclear receptor coactivator 7 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0R1
    Related
    ENSRNOP00000084173.1, ENSRNOT00000098212.2

  8. XM_063276551.1 → XP_063132621.1  nuclear receptor coactivator 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5XVX5, F1LWN1

  9. XM_063276544.1 → XP_063132614.1  nuclear receptor coactivator 7 isoform X1

    UniProtKB/TrEMBL
    F1LWN1

  10. XM_006227760.5 → XP_006227822.1  nuclear receptor coactivator 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y5Q5, A6JUS3
    Related
    ENSRNOP00000101437.1, ENSRNOT00000159673.1
    Conserved Domains (1) summary
    smart00584
    Location:59 → 221
    TLDc; domain in TBC and LysM domain containing proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools