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NCOA7 nuclear receptor coactivator 7 [ Homo sapiens (human) ]

Gene ID: 135112, updated on 21-Dec-2019

Summary

Official Symbol
NCOA7provided by HGNC
Official Full Name
nuclear receptor coactivator 7provided by HGNC
Primary source
HGNC:HGNC:21081
See related
Ensembl:ENSG00000111912 MIM:609752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESNA1; TLDC4; ERAP140; NCOA7-AS; Nbla00052; Nbla10993; dJ187J11.3
Expression
Ubiquitous expression in urinary bladder (RPKM 17.8), adrenal (RPKM 16.0) and 25 other tissues See more
Orthologs

Genomic context

See NCOA7 in Genome Data Viewer
Location:
6q22.31-q22.32
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (125780943..125932034)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126102307..126253176)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377986 Neighboring gene hes related family bHLH transcription factor with YRPW motif 2 Neighboring gene tRNA-Glu (anticodon CTC) 1-7 Neighboring gene NCOA7 antisense RNA 1 Neighboring gene RN7SK pseudogene 56 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45605, MGC88425

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear receptor coactivator 7
Names
140 kDa estrogen receptor-associated protein
TBC/LysM-associated domain containing 4
estrogen nuclear receptor coactivator 1
estrogen receptor associated protein 140 kDa
putative protein product of Nbla00052
putative protein product of Nbla10993

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122842.3NP_001116314.1  nuclear receptor coactivator 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK127512, AK294558, AL035689, AL834442, BX537385, DA770225
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    B3KXK4, Q8N3C8
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  2. NM_001199619.2NP_001186548.1  nuclear receptor coactivator 7 isoform 1

    See identical proteins and their annotated locations for NP_001186548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1. Variants 1, 3 and 4 encode the same longest isoform (1).
    Source sequence(s)
    AF493978, AL035689, AL078594, AL834442, BC137094, BX537385
    Consensus CDS
    CCDS5132.1
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    Q8N3C8
    Related
    ENSP00000357341.3, ENST00000368357.7
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  3. NM_001199620.2NP_001186549.1  nuclear receptor coactivator 7 isoform 1

    See identical proteins and their annotated locations for NP_001186549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR, compared to variant 1. Variants 1, 3 and 4 encode the same longest isoform (1).
    Source sequence(s)
    AF493978, AK294558, AL035689, AL078594, AL834442, BC137094, BX537385
    Consensus CDS
    CCDS5132.1
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    Q8N3C8
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  4. NM_001199621.2NP_001186550.1  nuclear receptor coactivator 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon, resulting in a downstream in-frame AUG start codon, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK294558, AL035689, AL834442, BC137094, BX537385, DA770225
    Consensus CDS
    CCDS56448.1
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    Q8N3C8
    Related
    ENSP00000229634.9, ENST00000229634.13
    Conserved Domains (2) summary
    smart00584
    Location:665827
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:1854
    LysM; LysM domain
  5. NM_001199622.2NP_001186551.1  nuclear receptor coactivator 7 isoform 4

    See identical proteins and their annotated locations for NP_001186551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple exons from the 5' end and has an alternate 5' exon, compared to variant 1. The resulting isoform (4) is much shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094706, AL035689, AL834442, BX537385, DA992384
    Consensus CDS
    CCDS83125.1
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    H0Y5F6, Q8N3C8
    Related
    ENSP00000398268.2, ENST00000438495.6
    Conserved Domains (1) summary
    smart00584
    Location:57219
    TLDc; domain in TBC and LysM domain containing proteins
  6. NM_181782.5NP_861447.3  nuclear receptor coactivator 7 isoform 1

    See identical proteins and their annotated locations for NP_861447.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 3 and 4 encode the same longest isoform (1).
    Source sequence(s)
    AK294558, AL035689, AL834442, BC137094, BX537385, DA770225
    Consensus CDS
    CCDS5132.1
    UniProtKB/Swiss-Prot
    Q8NI08
    UniProtKB/TrEMBL
    Q8N3C8
    Related
    ENSP00000376269.2, ENST00000392477.7
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    125780943..125932034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010274.2XP_016865763.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  2. XM_024446332.1XP_024302100.1  nuclear receptor coactivator 7 isoform X2

    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  3. XM_006715340.4XP_006715403.1  nuclear receptor coactivator 7 isoform X1

    See identical proteins and their annotated locations for XP_006715403.1

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  4. XM_017010270.1XP_016865759.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  5. XM_017010271.1XP_016865760.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  6. XM_011535455.2XP_011533757.1  nuclear receptor coactivator 7 isoform X1

    See identical proteins and their annotated locations for XP_011533757.1

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  7. XM_005266822.4XP_005266879.1  nuclear receptor coactivator 7 isoform X1

    See identical proteins and their annotated locations for XP_005266879.1

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  8. XM_024446331.1XP_024302099.1  nuclear receptor coactivator 7 isoform X1

    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  9. XM_017010272.2XP_016865761.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  10. XM_017010273.2XP_016865762.1  nuclear receptor coactivator 7 isoform X2

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:769931
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain
  11. XM_017010269.1XP_016865758.1  nuclear receptor coactivator 7 isoform X1

    UniProtKB/Swiss-Prot
    Q8NI08
    Conserved Domains (2) summary
    smart00584
    Location:780942
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:122158
    LysM; LysM domain

RNA

  1. XR_001743165.2 RNA Sequence

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