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OPRD1 opioid receptor delta 1 [ Homo sapiens (human) ]

Gene ID: 4985, updated on 1-Jun-2020

Summary

Official Symbol
OPRD1provided by HGNC
Official Full Name
opioid receptor delta 1provided by HGNC
Primary source
HGNC:HGNC:8153
See related
Ensembl:ENSG00000116329 MIM:165195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOP; DOR; DOR1; OPRD
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See OPRD1 in Genome Data Viewer
Location:
1p35.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28812170..28871267)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29138654..29190208)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 15715 Neighboring gene GATA motif-containing MPRA enhancer 282 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4082

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enkephalin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enkephalin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
opioid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of CREB transcription factor activity IC
Inferred by Curator
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
spine apparatus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
delta-type opioid receptor
Names
D-OR-1
DOR-1
delta opioid receptor 1
opioid receptor delta 1 isoform DOR-1B
opioid receptor delta 1 isoform DOR-1C
opioid receptor delta 1 isoform DOR-1D
opioid receptor delta 1 isoform DOR-1E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000911.4NP_000902.3  delta-type opioid receptor

    See identical proteins and their annotated locations for NP_000902.3

    Status: VALIDATED

    Source sequence(s)
    AL009181, BF434068, U10504
    Consensus CDS
    CCDS329.1
    UniProtKB/Swiss-Prot
    P41143
    Related
    ENSP00000234961.2, ENST00000234961.7
    Conserved Domains (2) summary
    pfam00001
    Location:66318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:59232
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28812170..28871267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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