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OMG oligodendrocyte myelin glycoprotein [ Homo sapiens (human) ]

Gene ID: 4974, updated on 3-May-2025
Official Symbol
OMGprovided by HGNC
Official Full Name
oligodendrocyte myelin glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:8135
See related
Ensembl:ENSG00000126861 MIM:164345; AllianceGenome:HGNC:8135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OMGP
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in neuron projection regeneration. Predicted to act upstream of or within regulation of collateral sprouting of intact axon in response to injury. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, May 2025]
Expression
Restricted expression toward brain (RPKM 57.3) See more
Orthologs
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See OMG in Genome Data Viewer
Location:
17q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31294647..31297239, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32240332..32242924, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29621665..29624257, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NF1 (neurofibromin 1) promoter region Neighboring gene MIR4733 host gene Neighboring gene ReSE screen-validated silencer GRCh37_chr17:29430681-29430862 Neighboring gene microRNA 4733 Neighboring gene neurofibromin 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:29471062-29471656 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:29471657-29472252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29472253-29472846 Neighboring gene NF1 intron 1 Alu-mediated recombination region Neighboring gene NF1 intron 2 Alu-mediated recombination region Neighboring gene NF1 intron 3 Alu-mediated recombination region Neighboring gene NF1 intron 8 Alu-mediated recombination region Neighboring gene uncharacterized LOC101927057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12010 Neighboring gene ecotropic viral integration site 2B Neighboring gene ecotropic viral integration site 2A

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection regeneration IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
oligodendrocyte-myelin glycoprotein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002544.5NP_002535.3  oligodendrocyte-myelin glycoprotein precursor

    See identical proteins and their annotated locations for NP_002535.3

    Status: VALIDATED

    Source sequence(s)
    AC134669, BC018050, DA206834
    Consensus CDS
    CCDS11265.1
    UniProtKB/Swiss-Prot
    E1P659, P23515
    UniProtKB/TrEMBL
    Q53HB8
    Related
    ENSP00000247271.4, ENST00000247271.5
    Conserved Domains (3) summary
    smart00013
    Location:2559
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:3756
    LRR_RI; leucine-rich repeat [structural motif]
    cl26018
    Location:45219
    NEL; C-terminal novel E3 ligase, LRR-interacting

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    31294647..31297239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791803.1 Reference GRCh38.p14 PATCHES

    Range
    373809..376401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    32240332..32242924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)