Omg oligodendrocyte myelin glycoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Omgprovided by MGI
Official Full Name: oligodendrocyte myelin glycoproteinprovided by MGI
Primary source: MGI:MGI:106586
See related: Ensembl:ENSMUSG00000049612 AllianceGenome:MGI:106586
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables identical protein binding activity. Acts upstream of or within neuron projection regeneration and regulation of collateral sprouting of intact axon in response to injury. Predicted to be located in myelin sheath and plasma membrane. Is expressed in brain. Orthologous to human OMG (oligodendrocyte myelin glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 42.4), cerebellum adult (RPKM 33.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.79 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (79391808..79394908, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (79500982..79504082, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study provided in vitro and in vivo evidence that endogenous OMgp plays an important role in oligodendrocyte differentiation and myelination
Title: Oligodendrocyte differentiation and myelination defects in OMgp null mice.
While myelin-derived axon growth inhibitor OMG may modulate axon sprouting, it does not play a major role in central nervous system axon regeneration failure.
Title: Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice.
This allelic series will aid in the study of OMgp in adult CNS axon regeneration using mouse models of spinal cord injury.
Title: Generation of an OMgp allelic series in mice.
Expression of Omg protein in the embryonic mouse telencephalon indicates Omg has a role in axonal target specification and synaptic plasticity.
Title: Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon.
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
Title: Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Omg (e-PCR), detects polymorphism
- UniSTS:495849

Homology

Homologs of the Omg gene: The Omg gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 344 organisms have orthologs with human gene Omg
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in neuron projection regeneration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within neuron projection regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting of intact axon in response to injury	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: oligodendrocyte-myelin glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019409.2 → NP_062282.2 oligodendrocyte-myelin glycoprotein precursor

See identical proteins and their annotated locations for NP_062282.2

Status: VALIDATED

Source sequence(s)

AK039141, BC024757, BY721452

Consensus CDS

CCDS25120.2

UniProtKB/Swiss-Prot

Q63912

UniProtKB/TrEMBL

G3XA53, Q8CAB4

Related

ENSMUSP00000132918.3, ENSMUST00000164465.3

Conserved Domains (4) summary

smart00013
Location:28 → 62

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:77 → 234

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:40 → 59

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:170 → 229

LRR_8; Leucine rich repeat