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ndc80 NDC80 kinetochore complex component [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 496580, updated on 17-Aug-2024

Summary

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Official Symbol
ndc80provided by Xenbase
Official Full Name
NDC80 kinetochore complex componentprovided by Xenbase
Primary source
Xenbase:XB-GENE-997352
See related
Ensembl:ENSXETG00000020840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
hec1; kntc2; xndc80
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (3357189..3374976, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683598.1 (40892..57939)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 1C Neighboring gene provisional ortholog of THAP domain containing 1 Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene karyopherin alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables kinetochore adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinetochore protein NDC80 homolog
Names
NDC80 homolog, kinetochore complex component
NDC80 kinetochore complex component homolog
kinetochore associated 2
kinetochore protein Hec1
kinetochore-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011162.1 → NP_001011162.1  kinetochore protein NDC80 homolog

    See identical proteins and their annotated locations for NP_001011162.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084918
    UniProtKB/Swiss-Prot
    Q5U4X5
    UniProtKB/TrEMBL
    A0A1B8Y124, A0A6I8S2Y0
    Related
    ENSXETP00000045005.3, ENSXETT00000045005.4
    Conserved Domains (2) summary
    COG5185
    Location:46 → 612
    HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
    pfam03801
    Location:50 → 205
    Ndc80_HEC; HEC/Ndc80p family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    3357189..3374976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012954423.3 → XP_012809877.1  kinetochore protein NDC80 homolog isoform X1

    See identical proteins and their annotated locations for XP_012809877.1

    UniProtKB/Swiss-Prot
    Q5U4X5
    UniProtKB/TrEMBL
    A0A1B8Y124, A0A6I8S2Y0
    Conserved Domains (2) summary
    COG5185
    Location:46 → 612
    HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
    pfam03801
    Location:50 → 205
    Ndc80_HEC; HEC/Ndc80p family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4X5.1 GenPept UniProtKB/Swiss-Prot:Q5U4X5

Gene LinkOut

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