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Ndc80 NDC80 kinetochore complex component [ Mus musculus (house mouse) ]

Gene ID: 67052, updated on 23-Jun-2021

Summary

Official Symbol
Ndc80provided by MGI
Official Full Name
NDC80 kinetochore complex componentprovided by MGI
Primary source
MGI:MGI:1914302
See related
Ensembl:ENSMUSG00000024056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HEC; HEC1; Kntc; Kntc2; AV139730; 2610020P18Rik
Expression
Biased expression in CNS E11.5 (RPKM 11.9), liver E14 (RPKM 11.3) and 9 other tissues See more
Orthologs
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Genomic context

See Ndc80 in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71803095..71833852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71496100..71526857, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (71845440..71876197, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SMC hinge domain containing 1 Neighboring gene ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit pseudogene Neighboring gene ubiquitin fusion degradation 1 like pseudogene Neighboring gene methyltransferase like 4, pseudogene 1 Neighboring gene speedy/RINGO cell cycle regulator family, member A Neighboring gene tRNA methyltransferase 61B Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/MI transition of meiotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centrosome duplication ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kinetochore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kinetochore organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metaphase plate congression ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis I IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spindle assembly involved in female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Ndc80 complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinetochore protein NDC80 homolog
Names
NDC80 homolog, kinetochore complex component
highly expressed in cancer, rich in leucine heptad repeats
kinetochore associated 2
kinetochore protein Hec1
kinetochore-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023294.2NP_075783.2  kinetochore protein NDC80 homolog

    See identical proteins and their annotated locations for NP_075783.2

    Status: VALIDATED

    Source sequence(s)
    AF326730, AK011497, BX527376, CJ201671
    Consensus CDS
    CCDS28959.1
    UniProtKB/Swiss-Prot
    Q9D0F1
    Related
    ENSMUSP00000024851.10, ENSMUST00000024851.10
    Conserved Domains (3) summary
    COG5185
    Location:48619
    HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
    pfam03801
    Location:51205
    Ndc80_HEC; HEC/Ndc80p family
    cl19219
    Location:324394
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71803095..71833852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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