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OAZ1 ornithine decarboxylase antizyme 1 [ Homo sapiens (human) ]

Gene ID: 4946, updated on 21-Apr-2019

Summary

Official Symbol
OAZ1provided by HGNC
Official Full Name
ornithine decarboxylase antizyme 1provided by HGNC
Primary source
HGNC:HGNC:8095
See related
Ensembl:ENSG00000104904 MIM:601579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ1; AZI; OAZ
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 404.8), lymph node (RPKM 286.9) and 25 other tissues See more
Orthologs

Genomic context

See OAZ1 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (2269486..2273488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2269520..2273487)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene uncharacterized LOC105372240 Neighboring gene PEAK family member 3 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene uncharacterized LOC101928572

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora A signaling, organism-specific biosystem
    Aurora A signaling
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
    Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
  • Nucleotide Metabolism, organism-specific biosystem (from WikiPathways)
    Nucleotide Metabolism, organism-specific biosystemThe pathway outlined above focuses on purine metabolism and in particular that of guanine metabolism.
  • Regulation of ornithine decarboxylase (ODC), organism-specific biosystem (from REACTOME)
    Regulation of ornithine decarboxylase (ODC), organism-specific biosystemPolyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138338

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ornithine decarboxylase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ornithine decarboxylase antizyme 1
Names
ODC-Az
antizyme 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301020.1NP_001287949.1  ornithine decarboxylase antizyme 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1.
    Source sequence(s)
    BC100291, BM423450, HY050868
    Consensus CDS
    CCDS77214.1
    UniProtKB/TrEMBL
    J3QQY4
    Related
    ENSP00000463955.3, ENST00000582888.8
    Conserved Domains (1) summary
    pfam02100
    Location:136215
    ODC_AZ; Ornithine decarboxylase antizyme
  2. NM_004152.3NP_004143.1  ornithine decarboxylase antizyme 1 isoform 1

    See identical proteins and their annotated locations for NP_004143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC100291, HY050868
    Consensus CDS
    CCDS58639.1
    UniProtKB/Swiss-Prot
    P54368
    Related
    ENSP00000473381.1, ENST00000602676.6
    Conserved Domains (1) summary
    pfam02100
    Location:138217
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    2269486..2273488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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