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Oaz1 ornithine decarboxylase antizyme 1 [ Mus musculus (house mouse) ]

Gene ID: 18245, updated on 23-May-2018
Official Symbol
Oaz1provided by MGI
Official Full Name
ornithine decarboxylase antizyme 1provided by MGI
Primary source
MGI:MGI:109433
See related
Ensembl:ENSMUSG00000035242 Vega:OTTMUSG00000042344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZ1; Oaz; AZ-1; ODC-Az; Antizyme
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in adrenal adult (RPKM 386.0), thymus adult (RPKM 368.7) and 28 other tissues See more
Orthologs
See Oaz1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (80826656..80829290)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80289401..80292035)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene microRNA 1982 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ornithine decarboxylase inhibitor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
ornithine decarboxylase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
ornithine decarboxylase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
ornithine decarboxylase antizyme 1
Names
antizyme 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301034.1NP_001287963.1  ornithine decarboxylase antizyme 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1.
    Source sequence(s)
    AA270439, AI838943, AK146571, BY112600
    Related
    ENSMUSP00000136469.1, OTTMUSP00000062507, ENSMUST00000177850.7, OTTMUST00000111592
    Conserved Domains (1) summary
    pfam02100
    Location:128216
    ODC_AZ; Ornithine decarboxylase antizyme
  2. NM_008753.4NP_032779.2  ornithine decarboxylase antizyme 1 isoform 1

    See identical proteins and their annotated locations for NP_032779.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI838943, AK146571, BY112600
    Consensus CDS
    CCDS56736.1
    UniProtKB/Swiss-Prot
    P54369
    Related
    ENSMUSP00000137400.1, OTTMUSP00000062508, ENSMUST00000180036.7, OTTMUST00000111593
    Conserved Domains (1) summary
    pfam02100
    Location:128218
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    80826656..80829290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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