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NUP88 nucleoporin 88 [ Homo sapiens (human) ]

Gene ID: 4927, updated on 26-Nov-2021

Summary

Official Symbol
NUP88provided by HGNC
Official Full Name
nucleoporin 88provided by HGNC
Primary source
HGNC:HGNC:8067
See related
Ensembl:ENSG00000108559 MIM:602552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FADS4
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in testis (RPKM 25.7), lymph node (RPKM 15.5) and 25 other tissues See more
Orthologs
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Genomic context

See NUP88 in Genome Data Viewer
Location:
17p13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (5384833..5419662, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5288153..5322982, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ZNF594 divergent transcript Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene uncharacterized LOC105371505 Neighboring gene RPA interacting protein Neighboring gene complement C1q binding protein Neighboring gene DEAH-box helicase 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with Nup88 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8530

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
enables transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal small subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear pore complex protein Nup88
Names
karyoporin
nuclear pore complex protein 88
nucleoporin 88kDa
nucleoporin Nup88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320653.2NP_001307582.1  nuclear pore complex protein Nup88 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004148, AK298158, AW089098, BC000335, BQ937933, BX956129, CX870338
    UniProtKB/Swiss-Prot
    Q99567
    UniProtKB/TrEMBL
    B4DP20
    Related
    ENSP00000225696.4, ENST00000225696.8
    Conserved Domains (2) summary
    pfam10168
    Location:14756
    Nup88; Nuclear pore component
    cl23943
    Location:596660
    PCRF; PCRF domain
  2. NM_002532.6NP_002523.2  nuclear pore complex protein Nup88 isoform 2

    See identical proteins and their annotated locations for NP_002523.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC004148, AW089098, BC000335, BQ937933, BX956129, CX870338
    Consensus CDS
    CCDS11070.1
    UniProtKB/Swiss-Prot
    Q99567
    Related
    ENSP00000458954.1, ENST00000573584.6
    Conserved Domains (1) summary
    pfam10168
    Location:14740
    Nup88; Nuclear pore component

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    5384833..5419662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024694.2XP_016880183.1  nuclear pore complex protein Nup88 isoform X2

  2. XM_011523893.3XP_011522195.1  nuclear pore complex protein Nup88 isoform X1

    See identical proteins and their annotated locations for XP_011522195.1

    UniProtKB/TrEMBL
    B4DP20
    Conserved Domains (2) summary
    pfam10168
    Location:1625
    Nup88; Nuclear pore component
    cl23943
    Location:465529
    PCRF; PCRF domain
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