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NUCB2 nucleobindin 2 [ Homo sapiens (human) ]

Gene ID: 4925, updated on 14-Jun-2018
Official Symbol
NUCB2provided by HGNC
Official Full Name
nucleobindin 2provided by HGNC
Primary source
HGNC:HGNC:8044
See related
Ensembl:ENSG00000070081 MIM:608020; Vega:OTTHUMG00000166050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEFA; HEL-S-109
Summary
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Expression
Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more
Orthologs
See NUCB2 in Genome Data Viewer
Location:
11p15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (17260337..17349980)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17281884..17371510)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene ribosomal protein L29 pseudogene 21 Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene uncharacterized LOC105376576 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene uncharacterized LOC107984316

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
nucleobindin-2
Names
DNA-binding protein NEFA
epididymis secretory protein Li 109
gastric cancer antigen Zg4
nesfatin 1
nucleobinding 2
prepronesfatin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330227.2NP_001317156.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  2. NM_001352661.1NP_001339590.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  3. NM_001352662.1NP_001339591.1  nucleobindin-2 isoform 4 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (1) summary
    cl25602
    Location:259370
    DUF3552; Domain of unknown function (DUF3552)
  4. NM_001352663.1NP_001339592.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  5. NM_001352664.1NP_001339593.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  6. NM_001352665.1NP_001339594.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  7. NM_001352666.1NP_001339595.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  8. NM_001352667.1NP_001339596.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Related
    ENSP00000408702.2, ENST00000458064.6
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  9. NM_001352668.1NP_001339597.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  10. NM_001352669.1NP_001339598.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  11. NM_001352670.1NP_001339599.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  12. NM_001352671.1NP_001339600.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  13. NM_001352672.1NP_001339601.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  14. NM_005013.3NP_005004.1  nucleobindin-2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005004.1

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Related
    ENSP00000436455.1, OTTHUMP00000231794, ENST00000529010.5
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    17260337..17349980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448537.1XP_024304305.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  2. XM_024448544.1XP_024304312.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  3. XM_017017815.1XP_016873304.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  4. XM_024448546.1XP_024304314.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  5. XM_024448543.1XP_024304311.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  6. XM_024448527.1XP_024304295.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  7. XM_024448548.1XP_024304316.1  nucleobindin-2 isoform X4

    Conserved Domains (1) summary
    cl25602
    Location:259370
    DUF3552; Domain of unknown function (DUF3552)
  8. XM_024448551.1XP_024304319.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  9. XM_024448533.1XP_024304301.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  10. XM_024448528.1XP_024304296.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  11. XM_024448550.1XP_024304318.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  12. XM_024448532.1XP_024304300.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  13. XM_017017818.2XP_016873307.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Related
    ENSP00000481959.1, ENST00000622082.4
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  14. XM_024448535.1XP_024304303.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  15. XM_017017826.1XP_016873315.1  nucleobindin-2 isoform X7

    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  16. XM_024448554.1XP_024304322.1  nucleobindin-2 isoform X6

    Conserved Domains (1) summary
    cl25602
    Location:259370
    DUF3552; Domain of unknown function (DUF3552)
  17. XM_024448553.1XP_024304321.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  18. XM_024448549.1XP_024304317.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  19. XM_024448531.1XP_024304299.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  20. XM_024448530.1XP_024304298.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  21. XM_024448547.1XP_024304315.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  22. XM_024448540.1XP_024304308.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  23. XM_017017828.1XP_016873317.1  nucleobindin-2 isoform X7

    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  24. XM_017017814.1XP_016873303.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  25. XM_024448542.1XP_024304310.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  26. XM_017017812.2XP_016873301.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  27. XM_024448538.1XP_024304306.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  28. XM_024448541.1XP_024304309.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  29. XM_024448552.1XP_024304320.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258369
    DUF3552; Domain of unknown function (DUF3552)
  30. XM_024448539.1XP_024304307.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  31. XM_017017813.1XP_016873302.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  32. XM_024448529.1XP_024304297.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  33. XM_024448536.1XP_024304304.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  34. XM_024448534.1XP_024304302.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  35. XM_017017817.1XP_016873306.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
  36. XM_024448545.1XP_024304313.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:305398
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_132751.1: Suppressed sequence

    Description
    NR_132751.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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