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NUCB2 nucleobindin 2 [ Homo sapiens (human) ]

Gene ID: 4925, updated on 9-Jan-2022

Summary

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Official Symbol
NUCB2provided by HGNC
Official Full Name
nucleobindin 2provided by HGNC
Primary source
HGNC:HGNC:8044
See related
Ensembl:ENSG00000070081 MIM:608020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEFA; HEL-S-109
Summary
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Expression
Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more
Orthologs
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Genomic context

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See NUCB2 in Genome Data Viewer
Location:
11p15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (17260337..17349980)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17298286..17353758)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene ribosomal protein L29 pseudogene 21 Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene uncharacterized LOC105376576 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene uncharacterized LOC107984316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Localization of nucleobindin2/nesfatin-1-like immunoreactivity in human lungs and neutrophils. Hui J, et al. Ann Anat, 2022 Jan. PMID 34082080
  2. The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis. Skorupska A, et al. Int J Mol Sci, 2021 May 26. PMID 34073612, Free PMC Article
  3. Detection of NUCB2/nesfatin-1 in cerebrospinal fluid of multiple sclerosis patients. Shimizu M, et al. Aging (Albany NY), 2020 Dec 12. PMID 33318307, Free PMC Article
  4. Increased serum nesfatin-1 levels in patients with acromegaly. Yang Y, et al. Medicine (Baltimore), 2020 Oct 2. PMID 33019423, Free PMC Article
  5. Nesfatin-1 Promotes Proliferation, Migration and Invasion of HTR-8/SVneo Trophoblast Cells and Inhibits Oxidative Stress via Activation of PI3K/AKT/mTOR and AKT/GSK3β Pathway. Li T, et al. Reprod Sci, 2021 Feb. PMID 32974855

See all (159) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma nesfatin-1 and DDP-4 levels in patients with coronary artery disease: Kozani study.
    Title: Plasma nesfatin-1 and DDP-4 levels in patients with coronary artery disease: Kozani study.
  2. Localization of nucleobindin2/nesfatin-1-like immunoreactivity in human lungs and neutrophils.
    Title: Localization of nucleobindin2/nesfatin-1-like immunoreactivity in human lungs and neutrophils.
  3. Nesfatin-1 Promotes Proliferation, Migration and Invasion of HTR-8/SVneo Trophoblast Cells and Inhibits Oxidative Stress via Activation of PI3K/AKT/mTOR and AKT/GSK3beta Pathway.
    Title: Nesfatin-1 Promotes Proliferation, Migration and Invasion of HTR-8/SVneo Trophoblast Cells and Inhibits Oxidative Stress via Activation of PI3K/AKT/mTOR and AKT/GSK3β Pathway.
  4. Nucleobindin 2/nesfatin-1 expression and colocalisation with neuropeptide Y and cocaine- and amphetamine-regulated transcript in the human brainstem.
    Title: Nucleobindin 2/nesfatin-1 expression and colocalisation with neuropeptide Y and cocaine- and amphetamine-regulated transcript in the human brainstem.
  5. Serum nesfatin-1 is associated with testosterone and the severity of erectile dysfunction.
    Title: Serum nesfatin-1 is associated with testosterone and the severity of erectile dysfunction.
  6. The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis.
    Title: The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis.
  7. Relationship of spontaneous subarachnoid haemorrhage and cerebral aneurysm to serum Visfatin and Nesfatin-1 levels.
    Title: Relationshıp of spontaneous subarachnoid haemorrhage and cerebral aneurysm to serum Visfatin and Nesfatin-1 levels.
  8. Detection of NUCB2/nesfatin-1 in cerebrospinal fluid of multiple sclerosis patients.
    Title: Detection of NUCB2/nesfatin-1 in cerebrospinal fluid of multiple sclerosis patients.
  9. Nesfatin-1 alleviates acute lung injury through reducing inflammation and oxidative stress via the regulation of HMGB1.
    Title: Nesfatin-1 alleviates acute lung injury through reducing inflammation and oxidative stress via the regulation of HMGB1.
  10. Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence.
    Title: Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence.
Submit: New GeneRIF Correction See all GeneRIFs (123)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of appetite IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nucleobindin-2
Names
DNA-binding protein NEFA
epididymis secretory protein Li 109
gastric cancer antigen Zg4
nesfatin 1
novel DNA binding/EF-hand/leucine zipper protein
nucleobinding 2
prepronesfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330227.3 → NP_001317156.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  2. NM_001352661.2 → NP_001339590.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    PRK12704
    Location:344 → 401
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:248 → 323
    EF-hand_7; EF-hand domain pair

  3. NM_001352662.2 → NP_001339591.1  nucleobindin-2 isoform 4 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (1) summary
    cl25602
    Location:259 → 370
    DUF3552; Domain of unknown function (DUF3552)

  4. NM_001352663.2 → NP_001339592.1  nucleobindin-2 isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Conserved Domains (2) summary
    PRK12704
    Location:344 → 401
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:248 → 323
    EF-hand_7; EF-hand domain pair

  5. NM_001352664.2 → NP_001339593.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  6. NM_001352665.2 → NP_001339594.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  7. NM_001352666.2 → NP_001339595.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  8. NM_001352667.2 → NP_001339596.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  9. NM_001352668.2 → NP_001339597.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  10. NM_001352669.2 → NP_001339598.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  11. NM_001352670.2 → NP_001339599.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  12. NM_001352671.2 → NP_001339600.1  nucleobindin-2 isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS81556.1
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  13. NM_001352672.2 → NP_001339601.1  nucleobindin-2 isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  14. NM_005013.4 → NP_005004.1  nucleobindin-2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_005004.1

    Status: VALIDATED

    Source sequence(s)
    AC107956, KF455328
    Consensus CDS
    CCDS41623.1
    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Related
    ENSP00000436455.1, ENST00000529010.6
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    17260337..17349980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448537.1 → XP_024304305.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  2. XM_024448544.1 → XP_024304312.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  3. XM_017017815.1 → XP_016873304.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  4. XM_024448546.1 → XP_024304314.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  5. XM_024448543.1 → XP_024304311.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  6. XM_024448527.1 → XP_024304295.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248 → 324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306 → 399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  7. XM_024448548.1 → XP_024304316.1  nucleobindin-2 isoform X4

    Conserved Domains (1) summary
    cl25602
    Location:259 → 370
    DUF3552; Domain of unknown function (DUF3552)

  8. XM_024448551.1 → XP_024304319.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  9. XM_024448533.1 → XP_024304301.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  10. XM_024448528.1 → XP_024304296.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248 → 324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306 → 399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  11. XM_024448550.1 → XP_024304318.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  12. XM_024448532.1 → XP_024304300.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  13. XM_017017818.2 → XP_016873307.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  14. XM_024448535.1 → XP_024304303.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  15. XM_017017826.1 → XP_016873315.1  nucleobindin-2 isoform X7

    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  16. XM_024448554.1 → XP_024304322.1  nucleobindin-2 isoform X6

    Conserved Domains (1) summary
    cl25602
    Location:259 → 370
    DUF3552; Domain of unknown function (DUF3552)

  17. XM_024448553.1 → XP_024304321.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  18. XM_024448549.1 → XP_024304317.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  19. XM_024448531.1 → XP_024304299.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  20. XM_024448530.1 → XP_024304298.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248 → 324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306 → 399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  21. XM_024448547.1 → XP_024304315.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  22. XM_024448540.1 → XP_024304308.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  23. XM_017017828.1 → XP_016873317.1  nucleobindin-2 isoform X7

    UniProtKB/TrEMBL
    Q2L696
    Conserved Domains (1) summary
    PRK12704
    Location:258 → 369
    PRK12704; phosphodiesterase; Provisional

  24. XM_017017814.1 → XP_016873303.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  25. XM_024448542.1 → XP_024304310.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  26. XM_017017812.2 → XP_016873301.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Related
    ENSP00000320168.6, ENST00000323688.10
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  27. XM_024448538.1 → XP_024304306.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  28. XM_024448541.1 → XP_024304309.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  29. XM_024448552.1 → XP_024304320.1  nucleobindin-2 isoform X5

    Conserved Domains (1) summary
    cl25602
    Location:258 → 369
    DUF3552; Domain of unknown function (DUF3552)

  30. XM_024448539.1 → XP_024304307.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  31. XM_017017813.1 → XP_016873302.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  32. XM_024448529.1 → XP_024304297.1  nucleobindin-2 isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:248 → 324
    EF-hand_7; EF-hand domain pair
    cl25632
    Location:306 → 399
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  33. XM_024448536.1 → XP_024304304.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  34. XM_024448534.1 → XP_024304302.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  35. XM_017017817.1 → XP_016873306.1  nucleobindin-2 isoform X3

    UniProtKB/Swiss-Prot
    P80303
    UniProtKB/TrEMBL
    V9HW75
    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

  36. XM_024448545.1 → XP_024304313.1  nucleobindin-2 isoform X2

    Conserved Domains (2) summary
    PRK12704
    Location:343 → 400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247 → 322
    EF-hand_7; EF-hand domain pair

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_132751.1: Suppressed sequence

    Description
    NR_132751.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80303.3 GenPept UniProtKB/Swiss-Prot:P80303

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