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Nucb2 nucleobindin 2 [ Mus musculus (house mouse) ]

Gene ID: 53322, updated on 14-Aug-2019

Summary

Official Symbol
Nucb2provided by MGI
Official Full Name
nucleobindin 2provided by MGI
Primary source
MGI:MGI:1858179
See related
Ensembl:ENSMUSG00000030659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nefa; Calnuc; AI607786; Nesfatin-1
Expression
Broad expression in genital fat pad adult (RPKM 8.5), bladder adult (RPKM 5.1) and 20 other tissues See more
Orthologs

Genomic context

See Nucb2 in Genome Data Viewer
Location:
7; 7 F1
Exon count:
16
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (116504352..116540588)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (123647888..123684102)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene predicted gene, 40453 Neighboring gene predicted gene, 32676 Neighboring gene predicted gene 9197 Neighboring gene predicted gene, 46018

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
insulin metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of testosterone secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleobindin-2
Names
DNA-binding protein NEFA
prepronefastin
prepronesfatin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130479.2NP_001123951.1  nucleobindin-2 precursor

    See identical proteins and their annotated locations for NP_001123951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC163222, AK152672, AK160442, BF462404, BY142521
    Consensus CDS
    CCDS52372.1
    UniProtKB/Swiss-Prot
    P81117
    UniProtKB/TrEMBL
    Q3TV28
    Related
    ENSMUSP00000032895.7, ENSMUST00000032895.14
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25602
    Location:343400
    DUF3552; Domain of unknown function (DUF3552)
  2. NM_001360375.1NP_001347304.1  nucleobindin-2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC163222
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25602
    Location:343400
    DUF3552; Domain of unknown function (DUF3552)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p6 C57BL/6J

    Range
    116504352..116540588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508027.2XP_006508090.1  nucleobindin-2 isoform X2

    See identical proteins and their annotated locations for XP_006508090.1

    Conserved Domains (1) summary
    COG1429
    Location:24196
    CobN; Cobalamin biosynthesis protein CobN, Mg-chelatase [Coenzyme transport and metabolism]
  2. XM_006508026.3XP_006508089.1  nucleobindin-2 isoform X2

    See identical proteins and their annotated locations for XP_006508089.1

  3. XM_006508028.2XP_006508091.1  nucleobindin-2 isoform X3

    See identical proteins and their annotated locations for XP_006508091.1

  4. XM_006508025.3XP_006508088.1  nucleobindin-2 isoform X1

    See identical proteins and their annotated locations for XP_006508088.1

    UniProtKB/Swiss-Prot
    P81117
    Conserved Domains (2) summary
    pfam13499
    Location:247323
    EF-hand_7; EF-hand domain pair
    cl25602
    Location:343400
    DUF3552; Domain of unknown function (DUF3552)

RNA

  1. XR_003946513.1 RNA Sequence

  2. XR_378260.2 RNA Sequence

  3. XR_001785587.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016773.3: Suppressed sequence

    Description
    NM_016773.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3' end.
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