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Nucb2 nucleobindin 2 [ Mus musculus (house mouse) ]

Gene ID: 53322, updated on 18-Apr-2024

Summary

Official Symbol
Nucb2provided by MGI
Official Full Name
nucleobindin 2provided by MGI
Primary source
MGI:MGI:1858179
See related
Ensembl:ENSMUSG00000030659 AllianceGenome:MGI:1858179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nefa; Calnuc; Nesfatin-1
Summary
Enables calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of appetite; negative regulation of cell communication; and positive regulation of testosterone secretion. Predicted to act upstream of or within cellular calcium ion homeostasis. Located in endoplasmic reticulum and nuclear outer membrane. Is expressed in several structures, including extraembryonic component and female reproductive system. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 8.5), bladder adult (RPKM 5.1) and 20 other tissues See more
Orthologs
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Genomic context

Location:
7 F1; 7 61.79 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (116103579..116139823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (116504352..116540588)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene STARR-positive B cell enhancer ABC_E9113 Neighboring gene predicted gene, 40453 Neighboring gene STARR-positive B cell enhancer ABC_E2844 Neighboring gene STARR-positive B cell enhancer mm9_chr7:123647630-123647931 Neighboring gene predicted gene, 32676 Neighboring gene RIKEN cDNA 4732496C06 gene Neighboring gene predicted gene 9197

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleobindin-2
Names
DNA-binding protein NEFA
prepronefastin
prepronesfatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130479.2NP_001123951.1  nucleobindin-2 precursor

    See identical proteins and their annotated locations for NP_001123951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC163222, AK152672, AK160442, BF462404, BY142521
    Consensus CDS
    CCDS52372.1
    UniProtKB/Swiss-Prot
    P81117
    UniProtKB/TrEMBL
    Q3UKN6
    Related
    ENSMUSP00000032895.8, ENSMUST00000032895.15
    Conserved Domains (2) summary
    PRK12704
    Location:343400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247322
    EF-hand_7; EF-hand domain pair
  2. NM_001360375.1NP_001347304.1  nucleobindin-2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC163222
    Consensus CDS
    CCDS52372.1
    UniProtKB/Swiss-Prot
    P81117
    UniProtKB/TrEMBL
    Q3UKN6
    Conserved Domains (2) summary
    PRK12704
    Location:343400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247322
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    116103579..116139823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508025.4XP_006508088.1  nucleobindin-2 isoform X1

    See identical proteins and their annotated locations for XP_006508088.1

    UniProtKB/Swiss-Prot
    P81117
    UniProtKB/TrEMBL
    Q3UKN6
    Conserved Domains (2) summary
    PRK12704
    Location:343400
    PRK12704; phosphodiesterase; Provisional
    pfam13499
    Location:247322
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_004934144.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016773.3: Suppressed sequence

    Description
    NM_016773.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain intronic sequence at its 3' end.