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NUCB1 nucleobindin 1 [ Homo sapiens (human) ]

Gene ID: 4924, updated on 5-Sep-2021

Summary

Official Symbol
NUCB1provided by HGNC
Official Full Name
nucleobindin 1provided by HGNC
Primary source
HGNC:HGNC:8043
See related
Ensembl:ENSG00000104805 MIM:601323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUC; CALNUC
Summary
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in kidney (RPKM 89.1), fat (RPKM 86.3) and 25 other tissues See more
Orthologs
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Genomic context

See NUCB1 in Genome Data Viewer
Location:
19q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48900312..48923372)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49403569..49426629)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated FTL and NUCB1 regulatory element Neighboring gene CRISPRi-validated cis-regulatory element chr19.5328 Neighboring gene TUB like protein 2 Neighboring gene CRISPRi-FlowFISH-validated BAX and NUCB1 regulatory element Neighboring gene NUCB1 antisense RNA 1 Neighboring gene dihydrodiol dehydrogenase Neighboring gene Sharpr-MPRA regulatory region 12688

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40471, DKFZp686A15286

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein targeting IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in extrinsic component of Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lumenal side of Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006184.6NP_006175.2  nucleobindin-1 precursor

    See identical proteins and their annotated locations for NP_006175.2

    Status: REVIEWED

    Source sequence(s)
    AC026803, AI208532, AK315422
    Consensus CDS
    CCDS12740.1
    UniProtKB/Swiss-Prot
    Q02818
    UniProtKB/TrEMBL
    A8K7Q1
    Related
    ENSP00000385923.3, ENST00000405315.9
    Conserved Domains (1) summary
    pfam13499
    Location:246319
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48900312..48923372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026845.1XP_016882334.1  nucleobindin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q02818
    Conserved Domains (1) summary
    pfam13499
    Location:246319
    EF-hand_7; EF-hand domain pair
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