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Nucb1 nucleobindin 1 [ Mus musculus (house mouse) ]

Gene ID: 18220, updated on 16-Oct-2021

Summary

Official Symbol
Nucb1provided by MGI
Official Full Name
nucleobindin 1provided by MGI
Primary source
MGI:MGI:97388
See related
Ensembl:ENSMUSG00000030824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nucb; C77483; Calnuc; MTEST82; B230337F23Rik
Expression
Ubiquitous expression in colon adult (RPKM 160.1), genital fat pad adult (RPKM 128.0) and 28 other tissues See more
Orthologs
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Genomic context

See Nucb1 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45142098..45159832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45492674..45510408, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52748044..52765778, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of protein targeting ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi cisterna membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lumenal side of Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163662.1NP_001157134.1  nucleobindin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151602, AK140710, AK160981
    Consensus CDS
    CCDS52247.1
    UniProtKB/Swiss-Prot
    Q02819
    Related
    ENSMUSP00000147383.2, ENSMUST00000211765.2
    Conserved Domains (1) summary
    pfam13499
    Location:245318
    EF-hand_7; EF-hand domain pair
  2. NM_008749.2NP_032775.1  nucleobindin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC151602, AK140710, AK160981
    Consensus CDS
    CCDS85300.1
    UniProtKB/Swiss-Prot
    Q02819
    UniProtKB/TrEMBL
    A0A1C7CYU3
    Related
    ENSMUSP00000033096.9, ENSMUST00000033096.16
    Conserved Domains (1) summary
    pfam13499
    Location:245318
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45142098..45159832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540696.4XP_006540759.1  nucleobindin-1 isoform X1

    See identical proteins and their annotated locations for XP_006540759.1

    UniProtKB/Swiss-Prot
    Q02819
    Conserved Domains (1) summary
    pfam13499
    Location:245318
    EF-hand_7; EF-hand domain pair
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