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Nucb1 nucleobindin 1 [ Mus musculus (house mouse) ]

Gene ID: 18220, updated on 30-Nov-2022

Summary

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Official Symbol
Nucb1provided by MGI
Official Full Name
nucleobindin 1provided by MGI
Primary source
MGI:MGI:97388
See related
Ensembl:ENSMUSG00000030824 AllianceGenome:MGI:97388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nucb; Calnuc; MTEST82; B230337F23Rik
Summary
Predicted to enable G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of protein targeting and small GTPase mediated signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and rough endoplasmic reticulum. Predicted to be extrinsic component of Golgi membrane. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human NUCB1 (nucleobindin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 160.1), genital fat pad adult (RPKM 128.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nucb1 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45142098..45159832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45492674..45510408, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues. Williams P, et al. Cell Tissue Res, 2014 Nov. PMID 25038744
  2. Novel autoimmune phenomena induced in vivo by a new DNA binding protein Nuc: a study on MRL/n mice. Kanai Y, et al. Immunol Lett, 1993 Dec. PMID 8144193
  3. CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models. Xue F, et al. Cell Signal, 2016 Aug. PMID 27178152
  4. Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis. Lin P, et al. J Neurochem, 2007 Mar. PMID 17348862
  5. Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Lavoie C, et al. Mol Endocrinol, 2002 Nov. PMID 12403836

See all (37) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chaperone protein Hsp70 was found to be important for CHIP and NUCB1 interaction as well as CHIP-mediated NUCB1 down-regulation.
    Title: CHIP mediates down-regulation of nucleobindin-1 in preosteoblast cell line models.
  2. the expression and distribution of NUCB1 in tissues and cells of the mouse endocrine system, was examined.
    Title: Expression of nucleobindin 1 (NUCB1) in pancreatic islets and other endocrine tissues.
  3. This protein is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells.
    Title: Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lumenal side of Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleobindin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163662.2 → NP_001157134.1  nucleobindin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS52247.1
    UniProtKB/Swiss-Prot
    Q02819, Q9DBL3
    UniProtKB/TrEMBL
    A0A6P5Q2X2
    Related
    ENSMUSP00000147383.2, ENSMUST00000211765.2
    Conserved Domains (1) summary
    pfam13499
    Location:245 → 318
    EF-hand_7; EF-hand domain pair

  2. NM_008749.3 → NP_032775.1  nucleobindin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC151602
    Consensus CDS
    CCDS85300.1
    UniProtKB/Swiss-Prot
    Q02819
    UniProtKB/TrEMBL
    A0A1C7CYU3
    Related
    ENSMUSP00000033096.9, ENSMUST00000033096.16
    Conserved Domains (1) summary
    pfam13499
    Location:245 → 318
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45142098..45159832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540696.4 → XP_006540759.1  nucleobindin-1 isoform X1

    See identical proteins and their annotated locations for XP_006540759.1

    UniProtKB/Swiss-Prot
    Q02819, Q9DBL3
    UniProtKB/TrEMBL
    A0A6P5Q2X2
    Conserved Domains (1) summary
    pfam13499
    Location:245 → 318
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02819.2 GenPept UniProtKB/Swiss-Prot:Q02819

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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