Format

Send to:

Choose Destination

NTRK3 neurotrophic receptor tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 4916, updated on 17-Sep-2017
Official Symbol
NTRK3provided by HGNC
Official Full Name
neurotrophic receptor tyrosine kinase 3provided by HGNC
Primary source
HGNC:HGNC:8033
See related
Ensembl:ENSG00000140538 MIM:191316; Vega:OTTHUMG00000148677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRKC; GP145-TrkC; gp145(trkC)
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Orthologs
Location:
15q25.3
Exon count:
36
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (87859749..88256796, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (88419948..88800026, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724465 Neighboring gene RNA, U6 small nuclear 185, pseudogene Neighboring gene long intergenic non-protein coding RNA 52 Neighboring gene mediator complex subunit 28 pseudogene 6 Neighboring gene uncharacterized LOC105370957 Neighboring gene NTRK3 antisense RNA 1 Neighboring gene uncharacterized LOC105370958

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons PubMed

Go to the HIV-1, Human Interaction Database

  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
    Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
    Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
neurotrophin binding TAS
Traceable Author Statement
more info
PubMed 
neurotrophin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
modulation by virus of host transcription IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate specification IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neurotrophin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension involved in regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
NT-3 growth factor receptor
Names
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
ETV6-NTRK3 fusion
neurotrophic tyrosine kinase, receptor, type 3
tyrosine kinase receptor C
NP_001007157.1
NP_001012338.1
NP_001230030.1
NP_001307063.1
NP_001307064.1
NP_002521.2
XP_006720606.1
XP_006720607.1
XP_006720608.1
XP_006720611.1
XP_006720612.1
XP_006720613.1
XP_011519939.1
XP_011519940.1
XP_016877729.1
XP_016877730.1
XP_016877731.1
XP_016877732.1
XP_016877733.1
XP_016877734.1
XP_016877735.1
XP_016877736.1
XP_016877737.1
XP_016877738.1
XP_016877739.1
XP_016877740.1
XP_016877741.1
XP_016877742.1
XP_016877743.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029619.1 RefSeqGene

    Range
    5001..384975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007156.2NP_001007157.1  NT-3 growth factor receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001007157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC021677, BC013693, BM675026, DA789502
    Consensus CDS
    CCDS32323.1
    UniProtKB/TrEMBL
    Q96CY4
    Related
    ENSP00000444673.2, ENST00000540489.6
    Conserved Domains (5) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. NM_001012338.2NP_001012338.1  NT-3 growth factor receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001012338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC009711, AC011966, DA789502, S76475
    Consensus CDS
    CCDS32322.1
    UniProtKB/Swiss-Prot
    Q16288
    UniProtKB/TrEMBL
    X5D2R1
    Related
    ENSP00000354207.2, ENST00000360948.6
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538824
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. NM_001243101.1NP_001230030.1  NT-3 growth factor receptor isoform d precursor

    See identical proteins and their annotated locations for NP_001230030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a.
    Source sequence(s)
    AC011966, AK313646, DA789502
    Consensus CDS
    CCDS58399.1
    UniProtKB/TrEMBL
    X5DNW6
    Related
    ENSP00000347397.3, ENST00000355254.6
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:530802
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:524810
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  4. NM_001320134.1NP_001307063.1  NT-3 growth factor receptor isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC021677, AF058390, AK309695, BM675026, S76476
    UniProtKB/Swiss-Prot
    Q16288
    UniProtKB/TrEMBL
    O95193
    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  5. NM_001320135.1NP_001307064.1  NT-3 growth factor receptor isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK302504, CD370531, HY003065, S76476
    Consensus CDS
    CCDS81916.1
    UniProtKB/Swiss-Prot
    Q16288
    UniProtKB/TrEMBL
    B7Z7U4
    Related
    ENSP00000437773.2, OTTHUMP00000246909, ENST00000542733.6, OTTHUMT00000415277
    Conserved Domains (7) summary
    cd04971
    Location:221298
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:113203
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00410
    Location:120203
    IG_like; Immunoglobulin like
    sd00031
    Location:730
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:562
    LRR_8; Leucine rich repeat
    pfam16920
    Location:65110
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl21453
    Location:434614
    PKc_like; Protein Kinases, catalytic domain
  6. NM_002530.3NP_002521.2  NT-3 growth factor receptor isoform b precursor

    See identical proteins and their annotated locations for NP_002521.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC011966, AC021677, DA789502, U05012
    Consensus CDS
    CCDS10340.1
    UniProtKB/Swiss-Prot
    Q16288
    UniProtKB/TrEMBL
    X5D7M5
    Related
    ENSP00000377990.1, OTTHUMP00000192915, ENST00000394480.6, OTTHUMT00000309066
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538810
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

    Range
    87859749..88256796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022240.1XP_016877729.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    X5D7M5
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538810
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. XM_006720544.3XP_006720607.1  NT-3 growth factor receptor isoform X2

    See identical proteins and their annotated locations for XP_006720607.1

    UniProtKB/TrEMBL
    X5DNW6
    Related
    ENSP00000453959.1, OTTHUMP00000246908, ENST00000557856.5, OTTHUMT00000415275
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:530802
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:524810
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  3. XM_006720543.3XP_006720606.1  NT-3 growth factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006720606.1

    UniProtKB/TrEMBL
    X5D7M5
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538810
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  4. XM_017022253.1XP_016877742.1  NT-3 growth factor receptor isoform X18

    UniProtKB/Swiss-Prot
    Q16288
    UniProtKB/TrEMBL
    X5D2R1
    Related
    ENSP00000485864.1, OTTHUMP00000278391, ENST00000629765.2, OTTHUMT00000480548
    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538824
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  5. XM_017022254.1XP_016877743.1  NT-3 growth factor receptor isoform X19

    Conserved Domains (8) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00219
    Location:538835
    TyrKc; Tyrosine kinase, catalytic domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    cd05094
    Location:532843
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  6. XM_017022244.1XP_016877733.1  NT-3 growth factor receptor isoform X5

  7. XM_017022245.1XP_016877734.1  NT-3 growth factor receptor isoform X5

  8. XM_017022246.1XP_016877735.1  NT-3 growth factor receptor isoform X5

  9. XM_017022243.1XP_016877732.1  NT-3 growth factor receptor isoform X5

  10. XM_017022241.1XP_016877730.1  NT-3 growth factor receptor isoform X3

  11. XM_017022252.1XP_016877741.1  NT-3 growth factor receptor isoform X17

  12. XM_017022251.1XP_016877740.1  NT-3 growth factor receptor isoform X16

  13. XM_006720545.3XP_006720608.1  NT-3 growth factor receptor isoform X6

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cl21453
    Location:532712
    PKc_like; Protein Kinases, catalytic domain
  14. XM_017022242.1XP_016877731.1  NT-3 growth factor receptor isoform X4

    Related
    ENSP00000453511.1, OTTHUMP00000247313, ENST00000558676.5, OTTHUMT00000416153
  15. XM_017022248.1XP_016877737.1  NT-3 growth factor receptor isoform X9

  16. XM_017022247.1XP_016877736.1  NT-3 growth factor receptor isoform X8

  17. XM_011521637.2XP_011519939.1  NT-3 growth factor receptor isoform X7

    See identical proteins and their annotated locations for XP_011519939.1

    UniProtKB/TrEMBL
    Q96CY4
    Related
    ENSP00000318328.3, OTTHUMP00000240515, ENST00000317501.7, OTTHUMT00000403049
    Conserved Domains (5) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  18. XM_017022249.1XP_016877738.1  NT-3 growth factor receptor isoform X10

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  19. XM_006720548.3XP_006720611.1  NT-3 growth factor receptor isoform X11

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  20. XM_006720550.3XP_006720613.1  NT-3 growth factor receptor isoform X13

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  21. XM_006720549.3XP_006720612.1  NT-3 growth factor receptor isoform X12

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  22. XM_011521638.2XP_011519940.1  NT-3 growth factor receptor isoform X15

    Conserved Domains (7) summary
    cd04971
    Location:319396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:3156
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:218301
    IG_like; Immunoglobulin like
    sd00031
    Location:105128
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:103160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  23. XM_017022250.1XP_016877739.1  NT-3 growth factor receptor isoform X14

RNA

  1. XR_001751292.1 RNA Sequence

  2. XR_001751293.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    88261800..88641816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center