NTRK1 neurotrophic receptor tyrosine kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTRK1provided by HGNC
Official Full Name: neurotrophic receptor tyrosine kinase 1provided by HGNC
Primary source: HGNC:HGNC:8031
See related: Ensembl:ENSG00000198400 MIM:191315
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal (RPKM 3.7), testis (RPKM 1.0) and 10 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1q23.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	1	NC_000001.11 (156815750..156881850)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156785542..156851642)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Two novel compound heterozygous variants of NTRK1 (c.632T > A and c.1253_1254delTC) were identified in a pair of Chinese identical twins with Congenital Insensitivity to Pain and Anhidrosis.
Title: Phenotypic and genotypic features of a pair of Chinese identical twins with congenital insensitivity to pain and anhidrosis: A case report.
The above results suggest that rutin preconditioning ameliorates cerebral I/R injury in OVX rats through ER-mediated BDNF-TrkB and NGF-TrkA signaling.
Title: Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
The TrkA peptide is competitive for metal binding with analogous peptides due to the N-terminal domain of NGF. These data provide cues for future exploration of the effect of metal ions on the activity of the NGF and its specific cellular receptor.
Title: Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link.
The LMNA-NTRK1 fusion was likely the molecular driver of tumorigenesis and metastasis in this patient, and the observed effectiveness of crizotinib treatment provides clinical validation of this molecular target.
Title: A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report.
that lipofibromatosis-like tumour represents a novel entity of NTRK1-associated neoplasms
Title: Lipofibromatosis-like neural tumour: a clinicopathological study of ten additional cases of an emerging novel entity.
System xC(-)-mediated TrkA activation therefore presents a promising target for therapeutic intervention in cancer pain treatment.
Title: Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain.
Results identified two known splice-site mutations, one known nonsense mutation and one novel missense mutation in three congenital insensitivity to pain with anhidrosis (CIPA) pedigrees. These findings expanded the spectrum of the NTRK1 mutations associated with CIPA patients, provided additional clues for the phenotype-genotype relationship beneath CIPA.
Title: Identification of a novel mutation of the NTRK1 gene in patients with congenital insensitivity to pain with anhidrosis (CIPA).
27 mutations in NTRK1 from Congenital insensitivity to pain with anhidrosis cohort, including 15 novel mutations, are reported.
Title: Novel NTRK1 mutations in Chinese patients with congenital insensitivity to pain with anhidrosis.
NTRK1 was upregulated in 80% of head and neck squamous carcinoma tissue.
Title: Nerve Growth Factor (NGF)-Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma.
TRKA expression can be found in 1.6% of solid tumours and can be paralleled by NTRK1 gene rearrangements or mostly copy number gain
Title: TRKA expression and NTRK1 gene copy number across solid tumours.

Submit: New GeneRIF Correction See all GeneRIFs (203)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in NTRK1 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Familial medullary thyroid carcinoma MedGen: C1833921 OMIM: 155240 GeneReviews: Multiple Endocrine Neoplasia Type 2	Compare labs
Hereditary insensitivity to pain with anhidrosis MedGen: C0020074 OMIM: 256800 GeneReviews: Congenital Insensitivity to Pain with Anhidrosis, Congenital Insensitivity to Pain Overview	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons	PubMed
Vpr	vpr	Treatment of cultured dorsal root ganglion sensory neurons with HIV-1 Vpr downregulates expression of TrKA and pGSK3beta/GSK3beta proteins and pre-treatment with NGF inhibits this Vpr-induced downregulation of TrKA and pGSK3beta/GSK3beta	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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ARMS-mediated activation, organism-specific biosystem (from REACTOME)
ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
Central carbon metabolism in cancer, conserved biosystem (from KEGG)
Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Frs2-mediated activation, organism-specific biosystem (from REACTOME)
Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
PLC-gamma1 signalling, organism-specific biosystemThe activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosph...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Signalling to ERKs, organism-specific biosystem (from REACTOME)
Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
Signalling to RAS, organism-specific biosystem (from REACTOME)
Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
Signalling to STAT3, organism-specific biosystem (from REACTOME)
Signalling to STAT3, organism-specific biosystemNeurotrophin-induced increase in Signal transducer and activator of transcription 3 (STAT3; acute-phase response factor) activation appears to underly several downstream functions of neurotrophin sig...
Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
TRKA activation by NGF, organism-specific biosystem (from REACTOME)
TRKA activation by NGF, organism-specific biosystemNeurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. N...
Thyroid cancer, organism-specific biosystem (from KEGG)
Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Thyroid cancer, conserved biosystem (from KEGG)
Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:593920 (e-PCR)
- UniSTS:157979

RH70890 (e-PCR)
- UniSTS:85791

D1S506 (e-PCR)
- UniSTS:54122

PMC86471P1 (e-PCR)
- UniSTS:273529

D1S506 (e-PCR)
- UniSTS:88479

Homology

Homologs of the NTRK1 gene: The NTRK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 204 organisms have orthologs with human gene NTRK1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
kinase binding	IEA Inferred from Electronic Annotation more info
nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
neurotrophin p75 receptor binding	IEA Inferred from Electronic Annotation more info
neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	TAS Traceable Author Statement more info
transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
Sertoli cell development	IEA Inferred from Electronic Annotation more info
activation of MAPKK activity	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
axon guidance	IEA Inferred from Electronic Annotation more info
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to formalin induced pain	IEA Inferred from Electronic Annotation more info
NOT cellular response to amyloid-beta	IDA Inferred from Direct Assay more info	PubMed
cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to nerve growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
cellular response to nicotine	IEA Inferred from Electronic Annotation more info
circadian rhythm	IEA Inferred from Electronic Annotation more info
detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
learning or memory	IEA Inferred from Electronic Annotation more info
mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nerve growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
nervous system development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
neurotrophin TRK receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
neurotrophin TRK receptor signaling pathway	TAS Traceable Author Statement more info
olfactory nerve development	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
NOT positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
programmed cell death involved in cell development	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to axon injury	IEA Inferred from Electronic Annotation more info
response to electrical stimulus	IEA Inferred from Electronic Annotation more info
response to hydrostatic pressure	IEA Inferred from Electronic Annotation more info
response to nutrient levels	IEA Inferred from Electronic Annotation more info
response to radiation	IEA Inferred from Electronic Annotation more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
Golgi membrane	TAS Traceable Author Statement more info
axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell surface	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
early endosome	ISS Inferred from Sequence or Structural Similarity more info
early endosome membrane	IEA Inferred from Electronic Annotation more info
endosome membrane	TAS Traceable Author Statement more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
late endosome	ISS Inferred from Sequence or Structural Similarity more info
late endosome membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	TAS Traceable Author Statement more info
protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
receptor complex	IDA Inferred from Direct Assay more info	PubMed
recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity nerve growth factor receptor

Names: Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin-related kinase A; tyrosine kinase receptor A

NP_001007793.1

EC 2.7.10.1

NP_001012331.1

EC 2.7.10.1

NP_002520.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007493.1 RefSeqGene

Range

5001..71101

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_261

mRNA and Protein(s)

NM_001007792.1 → NP_001007793.1 high affinity nerve growth factor receptor isoform 3

See identical proteins and their annotated locations for NP_001007793.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) utilizes alternate 5' exons and lacks an internal in-frame exon, compared to variant 2. Translation initiation occurs at an upstream AUG, resulting in a shorter isoform (3) with a unique N-terminus compared to isoform 2.

Source sequence(s)

AL158169, BC062580

Consensus CDS

CCDS30890.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000376120.2, ENST00000392302.6

Conserved Domains (7) summary

cd04971
Location:269 → 349

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:165 → 252

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:468 → 747

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:63 → 86

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:474 → 745

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:62 → 120

LRR_8; Leucine rich repeat

pfam16920
Location:121 → 162

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001012331.1 → NP_001012331.1 high affinity nerve growth factor receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001012331.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an internal, in-frame exon, compared to variant 2, resulting in a shorter isoform (1) lacking an internal segment compared to isoform 2.

Source sequence(s)

BC062580, BM685020, M23102

Consensus CDS

CCDS30891.1

UniProtKB/Swiss-Prot

P04629

UniProtKB/TrEMBL

X5DR71

Related

ENSP00000357179.3, ENST00000368196.7

Conserved Domains (7) summary

cd04971
Location:299 → 379

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 → 282

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:498 → 777

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:504 → 775

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 192

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_002529.3 → NP_002520.2 high affinity nerve growth factor receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_002520.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

BC062580, M23102, X06704

Consensus CDS

CCDS1161.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000431418.1, ENST00000524377.5

Conserved Domains (7) summary

cd04971
Location:299 → 379

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 → 282

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:504 → 783

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:510 → 781

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 192

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain