NTRK1 neurotrophic receptor tyrosine kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTRK1provided by HGNC
Official Full Name: neurotrophic receptor tyrosine kinase 1provided by HGNC
Primary source: HGNC:HGNC:8031
See related: Ensembl:ENSG00000198400 MIM:191315
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal (RPKM 3.7), testis (RPKM 1.0) and 10 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1q23.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (156815750..156881850)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (156785542..156851642)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor.
Title: Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor.
Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib.
Title: Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib.
no association of evaluated polymorphisms of Nav1.7 or NTRK1 and trigeminal neuralgia diagnosis or pain severity was observed
Title: No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia.
Experts from several Institutions were recruited by the European Society for Medical Oncology (ESMO) Translational Research and Precision Medicine Working Group (TR and PM WG) to review the available methods for the detection of NTRK gene fusions, their potential applications, and strategies for the implementation of a rational approach for the detection of NTRK1/2/3 fusion genes in human malignancies.
Title: ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research.
TrkA mutants behave in the same way, at least concerning membrane mobility and ubiquitination. Two different TrkA membrane immobilization modes and demonstrate that not all kinase-inactive mutants display identical membrane trafficking.
Title: Molecular insight on the altered membrane trafficking of TrkA kinase dead mutants.
LMNA-NTRK1 fussion protein was found in refractory and metastatic infantile fibrosarcoma.
Title: Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib.
Describe Spitz tumors with NTRK1 fusion and distinctive histopathologic features characterized by filigree-like rete ridges which are elongated, thin and branched, dermal melanocytes arranged in a rosette-like configuration, and marked diminishment of melanocyte size with descent into the dermis.
Title: Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion.
TrkA/EphA2 functional association in proNGF-induced tumor promoting effects in breast cancer cells.
Title: ProNGF increases breast tumor aggressiveness through functional association of TrkA with EphA2.
It is crucial for the tumorigenesis and progression of neuroblastoma.
Title: The roles played by the MYCN, Trk, and ALK genes in neuroblastoma and neural development.
The G-allele of rs231775 in the CTLA-4 gene is associated with an improved OS in sunitinib-treated cc-mRCC patients and could potentially be used as a prognostic biomarker.
Title: Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model.

Submit: New GeneRIF Correction See all GeneRIFs (227)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in NTRK1 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Hereditary insensitivity to pain with anhidrosis MedGen: C0020074 OMIM: 256800 GeneReviews: NTRK1 Congenital Insensitivity to Pain with Anhidrosis, Congenital Insensitivity to Pain Overview	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env (gp120) exposure downregulates TrkA, TrkB, and TrkC mRNA levels in dorsal root ganglion neurons	PubMed
Vpr	vpr	Treatment of cultured dorsal root ganglion sensory neurons with HIV-1 Vpr downregulates expression of TrKA and pGSK3beta/GSK3beta proteins and pre-treatment with NGF inhibits this Vpr-induced downregulation of TrKA and pGSK3beta/GSK3beta	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:593920 (e-PCR)
- UniSTS:157979

RH70890 (e-PCR)
- UniSTS:85791

D1S506 (e-PCR)
- UniSTS:54122

PMC86471P1 (e-PCR)
- UniSTS:273529

D1S506 (e-PCR)
- UniSTS:88479

Homology

Homologs of the NTRK1 gene: The NTRK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 218 organisms have orthologs with human gene NTRK1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase binding	IEA Inferred from Electronic Annotation more info
nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
neurotrophin p75 receptor binding	IEA Inferred from Electronic Annotation more info
neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	TAS Traceable Author Statement more info
transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
Sertoli cell development	IEA Inferred from Electronic Annotation more info
activation of MAPKK activity	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
axon guidance	IEA Inferred from Electronic Annotation more info
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to formalin induced pain	IEA Inferred from Electronic Annotation more info
NOT cellular response to amyloid-beta	IDA Inferred from Direct Assay more info	PubMed
cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to nerve growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
cellular response to nicotine	IEA Inferred from Electronic Annotation more info
circadian rhythm	IEA Inferred from Electronic Annotation more info
detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
learning or memory	IEA Inferred from Electronic Annotation more info
mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nerve growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
neurotrophin TRK receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
neurotrophin TRK receptor signaling pathway	TAS Traceable Author Statement more info
olfactory nerve development	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
NOT positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
programmed cell death involved in cell development	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of protein kinase B signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to axon injury	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to electrical stimulus	IEA Inferred from Electronic Annotation more info
response to hydrostatic pressure	IEA Inferred from Electronic Annotation more info
response to nutrient levels	IEA Inferred from Electronic Annotation more info
response to radiation	IEA Inferred from Electronic Annotation more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
Golgi membrane	TAS Traceable Author Statement more info
axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell surface	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
early endosome	ISS Inferred from Sequence or Structural Similarity more info
early endosome membrane	IEA Inferred from Electronic Annotation more info
endosome membrane	TAS Traceable Author Statement more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
late endosome	ISS Inferred from Sequence or Structural Similarity more info
late endosome membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	TAS Traceable Author Statement more info
protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
receptor complex	IDA Inferred from Direct Assay more info	PubMed
recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity nerve growth factor receptor

Names: Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin-related kinase A; tyrosine kinase receptor A

NP_001007793.1

EC 2.7.10.1

NP_001012331.1

EC 2.7.10.1

NP_002520.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007493.1 RefSeqGene

Range

5001..71101

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_261

mRNA and Protein(s)

NM_001007792.1 → NP_001007793.1 high affinity nerve growth factor receptor isoform 3

See identical proteins and their annotated locations for NP_001007793.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) utilizes alternate 5' exons and lacks an internal in-frame exon, compared to variant 2. Translation initiation occurs at an upstream AUG, resulting in a shorter isoform (3) with a unique N-terminus compared to isoform 2.

Source sequence(s)

AL158169, BC062580

Consensus CDS

CCDS30890.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000376120.2, ENST00000392302.6

Conserved Domains (7) summary

cd04971
Location:269 → 349

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:165 → 252

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:468 → 747

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:63 → 86

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:474 → 745

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:62 → 120

LRR_8; Leucine rich repeat

pfam16920
Location:121 → 162

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_001012331.2 → NP_001012331.1 high affinity nerve growth factor receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001012331.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an internal, in-frame exon, compared to variant 2, resulting in a shorter isoform (1) lacking an internal segment compared to isoform 2.

Source sequence(s)

AL158169, BC062580, BM685020, M23102

Consensus CDS

CCDS30891.1

UniProtKB/Swiss-Prot

P04629

UniProtKB/TrEMBL

X5DR71

Related

ENSP00000357179.3, ENST00000368196.7

Conserved Domains (7) summary

cd04971
Location:299 → 379

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 → 282

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:498 → 777

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:504 → 775

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 192

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
NM_002529.4 → NP_002520.2 high affinity nerve growth factor receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_002520.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AL158169, BC062580, M23102, X06704

Consensus CDS

CCDS1161.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000431418.1, ENST00000524377.5

Conserved Domains (7) summary

cd04971
Location:299 → 379

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 → 282

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:504 → 783

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam07714
Location:510 → 781

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 192

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain