U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARHGAP44 Rho GTPase activating protein 44 [ Canis lupus familiaris (dog) ]

Gene ID: 489510, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
ARHGAP44provided by VGNC
Official Full Name
Rho GTPase activating protein 44provided by VGNC
Primary source
VGNC:VGNC:38065
See related
Ensembl:ENSCAFG00845003750
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ARHGAP44 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (36898675..37066421)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (36933812..37101416)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (37008878..37176525)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (36871586..37039378)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (36818449..36986578)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155247 Neighboring gene myocardin Neighboring gene translation initiation factor IF-2-like Neighboring gene elaC ribonuclease Z 2 Neighboring gene uncharacterized LOC102155885

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in modification of dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular anatomical structure IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in leading edge membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
rho GTPase-activating protein 44

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    36898675..37066421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665639.1 → XP_038521567.1  rho GTPase-activating protein 44 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RB88, A0A8C0Z2R4, A0A8I3MRN8
    Related
    ENSCAFP00845005386.1, ENSCAFT00845006773.1
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_038665640.1 → XP_038521568.1  rho GTPase-activating protein 44 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JL39, A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. XM_038665641.1 → XP_038521569.1  rho GTPase-activating protein 44 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JJS3, A0A8C0RB89, A0A8I3MQT1, A0A8I3MRL5, A0A8P0PBI9
    Related
    ENSCAFP00845005343.1, ENSCAFT00845006719.1
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  4. XM_038665642.1 → XP_038521570.1  rho GTPase-activating protein 44 isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z2R4, A0A8I3N6X8, A0A8P0TS88
    Related
    ENSCAFP00845005464.1, ENSCAFT00845006860.1
    Conserved Domains (2) summary
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:13 → 260
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_038665643.1 → XP_038521571.1  rho GTPase-activating protein 44 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    36871586..37039378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475738.1 → XP_038331666.1  rho GTPase-activating protein 44 isoform X1

  2. XM_038475741.1 → XP_038331669.1  rho GTPase-activating protein 44 isoform X4

  3. XM_038475742.1 → XP_038331670.1  rho GTPase-activating protein 44 isoform X5

  4. XM_038475739.1 → XP_038331667.1  rho GTPase-activating protein 44 isoform X2

  5. XM_038475740.1 → XP_038331668.1  rho GTPase-activating protein 44 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    36818449..36986578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601067.1 → XP_038456995.1  rho GTPase-activating protein 44 isoform X1

    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_038601070.1 → XP_038456998.1  rho GTPase-activating protein 44 isoform X4

    Conserved Domains (2) summary
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:13 → 260
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_038601071.1 → XP_038456999.1  rho GTPase-activating protein 44 isoform X5

    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  4. XM_038601068.1 → XP_038456996.1  rho GTPase-activating protein 44 isoform X2

    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  5. XM_038601069.1 → XP_038456997.1  rho GTPase-activating protein 44 isoform X3

    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    37008878..37176525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536921.1 → XP_038392849.1  rho GTPase-activating protein 44 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RB88, A0A8C0Z2R4, A0A8I3MRN8
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_038536924.1 → XP_038392852.1  rho GTPase-activating protein 44 isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z2R4, A0A8I3N6X8, A0A8P0TS88
    Conserved Domains (2) summary
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:13 → 260
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_038536925.1 → XP_038392853.1  rho GTPase-activating protein 44 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  4. XM_038536922.1 → XP_038392850.1  rho GTPase-activating protein 44 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JL39, A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  5. XM_038536923.1 → XP_038392851.1  rho GTPase-activating protein 44 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JJS3, A0A8C0RB89, A0A8I3MQT1, A0A8I3MRL5, A0A8P0PBI9
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    36933812..37101416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005620064.4 → XP_005620121.2  rho GTPase-activating protein 44 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RB88, A0A8C0Z2R4, A0A8I3MRN8
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_005620065.4 → XP_005620122.2  rho GTPase-activating protein 44 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JL39, A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  3. XM_005620066.4 → XP_005620123.2  rho GTPase-activating protein 44 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JJS3, A0A8C0RB89, A0A8I3MQT1, A0A8I3MRL5, A0A8P0PBI9
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  4. XM_022418596.2 → XP_022274304.2  rho GTPase-activating protein 44 isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z2R4, A0A8I3N6X8, A0A8P0TS88
    Conserved Domains (2) summary
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:13 → 260
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_005620067.4 → XP_005620124.2  rho GTPase-activating protein 44 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Z2R4
    Conserved Domains (2) summary
    cd07619
    Location:13 → 260
    BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
    cl02570
    Location:249 → 449
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials