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NRAS NRAS proto-oncogene, GTPase [ Homo sapiens (human) ]

Gene ID: 4893, updated on 1-Aug-2020

Summary

Official Symbol
NRASprovided by HGNC
Official Full Name
NRAS proto-oncogene, GTPaseprovided by HGNC
Primary source
HGNC:HGNC:7989
See related
Ensembl:ENSG00000213281 MIM:164790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
Summary
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 23.0), colon (RPKM 17.3) and 25 other tissues See more
Orthologs

Genomic context

See NRAS in Genome Data Viewer
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (114704469..114716771, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115247085..115259515, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene RNA, 7SL, cytoplasmic 432, pseudogene Neighboring gene cold shock domain containing E1 Neighboring gene RNY1 pseudogene 13 Neighboring gene suppressor of IKBKE 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Colorectal cancer
MedGen: C1527249 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Epidermal nevus
MedGen: C0334082 OMIM: 162900 GeneReviews: Not available
Compare labs
Epidermal nevus syndrome
MedGen: C0265318 OMIM: 163200 GeneReviews: Not available
Compare labs
Follicular thyroid carcinoma
MedGen: C4225426 OMIM: 188470 GeneReviews: Not available
Compare labs
Large congenital melanocytic nevus
MedGen: C1842036 OMIM: 137550 GeneReviews: Not available
Compare labs
Neurocutaneous melanocytosis
MedGen: C0544862 OMIM: 249400 GeneReviews: Not available
Compare labs
Noonan syndrome 6
MedGen: C2750732 OMIM: 613224 GeneReviews: Noonan Syndrome
Compare labs
RAS-associated autoimmune leukoproliferative disorder
MedGen: C2674723 OMIM: 614470 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common genetic variants on 1p13.2 associate with risk of autism.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NRAS PubMed
Knockdown of neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
Nef nef HIV-1 Nef-induced relocalization of LCK is correlated with N-Ras activation at recycling endosome/TGN compartments PubMed
Tat tat HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat PubMed
tat Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Ras protein signal transduction TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
GTPase NRas
Names
N-ras protein part 4
neuroblastoma RAS viral (v-ras) oncogene homolog
neuroblastoma RAS viral oncogene homolog
transforming protein N-Ras
v-ras neuroblastoma RAS viral oncogene homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007572.1 RefSeqGene

    Range
    5001..17438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_92

mRNA and Protein(s)

  1. NM_002524.5NP_002515.1  GTPase NRas

    See identical proteins and their annotated locations for NP_002515.1

    Status: REVIEWED

    Source sequence(s)
    AL096773, AW021410, AY941101, BC005219, BC013214
    Consensus CDS
    CCDS877.1
    UniProtKB/Swiss-Prot
    P01111
    UniProtKB/TrEMBL
    Q5U091
    Related
    ENSP00000358548.4, ENST00000369535.5
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    114704469..114716771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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