GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GABRA6provided by VGNC
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha6provided by VGNC
Primary source: VGNC:VGNC:51895
See related: Ensembl:ENSCAFG00845000820
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (49639863..49657617, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (49099501..49116828, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (50103326..50121062, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (49446978..49464698, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (49579983..49597659, complement)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables GABA-gated chloride ion channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables benzodiazepine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendrite membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit alpha-6

Names: gamma-aminobutyric acid type A receptor alpha6 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051808.1 Reference ROS_Cfam_1.0

Range

49639863..49657617 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038663447.1 → XP_038519375.1 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Related

ENSCAFP00845001052.1, ENSCAFT00845001363.1

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_038663446.1 → XP_038519374.1 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

Alternate UMICH_Zoey_3.1

Genomic

NC_049264.1 Alternate UMICH_Zoey_3.1

Range

49446978..49464698 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038473760.1 → XP_038329688.1 gamma-aminobutyric acid receptor subunit alpha-6

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_038473759.1 → XP_038329687.1 gamma-aminobutyric acid receptor subunit alpha-6

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049745.1 Alternate UNSW_CanFamBas_1.0

Range

49579983..49597659 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038599141.1 → XP_038455069.1 gamma-aminobutyric acid receptor subunit alpha-6
XM_038599140.1 → XP_038455068.1 gamma-aminobutyric acid receptor subunit alpha-6

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049225.1 Alternate UU_Cfam_GSD_1.0

Range

50103326..50121062 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038534840.1 → XP_038390768.1 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_038534839.1 → XP_038390767.1 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

49099501..49116828 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022417729.2 → XP_022273437.1 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
XM_546263.7 → XP_546263.2 gamma-aminobutyric acid receptor subunit alpha-6

UniProtKB/TrEMBL

A0A8C0JJC0, A0A8C0PW20, A0A8C0RKF4, A0A8I3MFI4

Conserved Domains (3) summary

TIGR00860
Location:34 → 440

LIC; Cation transporter family protein

cd03558
Location:156 → 170

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:42 → 239

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))