NPY neuropeptide Y [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPYprovided by HGNC
Official Full Name: neuropeptide Yprovided by HGNC
Primary source: HGNC:HGNC:7955
See related: Ensembl:ENSG00000122585 MIM:162640; AllianceGenome:HGNC:7955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PYY4
Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Expression: Biased expression in prostate (RPKM 182.5), brain (RPKM 56.2) and 1 other tissue See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7p15.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (24284190..24291862)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (24422184..24429876)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (24323809..24331481)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin.
Title: Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin.
Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome.
Title: Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome.
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions.
Title: Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions.
Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease.
Title: Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease.
Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.
Title: Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.
Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
Title: Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).
[Neuropeptide Y (NPY) gene and body mass index].", trans "Gen del neuropeptido Y (NPY), respuesta a la dieta e indice de masa corporal.
Title: [Neuropeptide Y (NPY) gene and body mass index].
Beta-endorphin-immunoreactive perikarya appear to receive innervation from NPY-immunoreactive fiber varicosities in the human hypothalamus.
Title: Β-endorphin-immunoreactive perikarya appear to receive innervation from NPY-immunoreactive fiber varicosities in the human hypothalamus.
Structural basis of neuropeptide Y signaling through Y1 receptor.
Title: Structural basis of neuropeptide Y signaling through Y1 receptor.

Submit: New GeneRIF Correction See all GeneRIFs (246)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Exploring the genetic basis of chronic periodontitis: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NPY (e-PCR)
- UniSTS:503619

NPY (e-PCR)
- UniSTS:29815

STS-M14298 (e-PCR)
- UniSTS:51186

Homology

Homologs of the NPY gene: The NPY gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 496 organisms have orthologs with human gene NPY
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in adult feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intestinal epithelial cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in monocyte activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron death	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of eating behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of nerve growth factor production	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in short-day photoperiodism	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal dense core vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: pro-neuropeptide Y

Names: prepro-neuropeptide Y

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.