U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NPY neuropeptide Y [ Homo sapiens (human) ]

Gene ID: 4852, updated on 22-Feb-2024

Summary

Official Symbol
NPYprovided by HGNC
Official Full Name
neuropeptide Yprovided by HGNC
Primary source
HGNC:HGNC:7955
See related
Ensembl:ENSG00000122585 MIM:162640; AllianceGenome:HGNC:7955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PYY4
Summary
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Expression
Biased expression in prostate (RPKM 182.5), brain (RPKM 56.2) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NPY in Genome Data Viewer
Location:
7p15.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (24284190..24291862)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (24422184..24429876)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (24323809..24331481)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986777 Neighboring gene RNA, 5S ribosomal pseudogene 228 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:24317744-24318943 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24365511-24365721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24383660-24384160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24388531-24389031 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24435498-24436157 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24436158-24436818 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24438272-24438926 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24440891-24441545 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24441546-24442200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25741 Neighboring gene NANOG hESC enhancer GRCh37_chr7:24446236-24446807 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24466273-24466844 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24466845-24467415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24472530-24473088 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24474463-24475000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25742 Neighboring gene uncharacterized LOC124901601 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24516814-24517478 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24517479-24518142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24518143-24518806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24518807-24519469 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24562031-24562238 Neighboring gene RNA, U6 small nuclear 1103, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
EBI GWAS Catalog
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
EBI GWAS Catalog
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide Y receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
involved_in adult feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in central nervous system neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intestinal epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic signaling via neuropeptide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal dense core vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
pro-neuropeptide Y
Names
prepro-neuropeptide Y

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016148.1 RefSeqGene

    Range
    5003..12675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000905.4NP_000896.1  pro-neuropeptide Y preproprotein

    See identical proteins and their annotated locations for NP_000896.1

    Status: REVIEWED

    Source sequence(s)
    AI198311, K01911
    Consensus CDS
    CCDS5387.1
    UniProtKB/Swiss-Prot
    P01303
    UniProtKB/TrEMBL
    A4D158
    Related
    ENSP00000242152.2, ENST00000242152.7
    Conserved Domains (1) summary
    smart00309
    Location:2964
    PAH; Pancreatic hormones / neuropeptide F / peptide YY family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    24284190..24291862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    24422184..24429876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)