KLK14 kallikrein related peptidase 14 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KLK14provided by VGNC
Official Full Name: kallikrein related peptidase 14provided by VGNC
Primary source: VGNC:VGNC:42481
See related: Ensembl:ENSCAFG00845014650
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (106321331..106325935)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (105384856..105389257)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (106429597..106434003)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (105993029..105997429)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (105634124..105638530)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In addition to the classical form of the gene, five splice variants were also identified. The splicing events involved 5'-truncation or complete elimination of exon 4 and/or retention of intron I.
Title: The canine kallikrein-related peptidase 14: structural characterization, alternative splicing and differential expression in mammary cancer.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermis morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in seminal clot liquefaction	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: kallikrein-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165879.1 → NP_001159351.1 kallikrein-14 precursor

See identical proteins and their annotated locations for NP_001159351.1

Status: PROVISIONAL

Source sequence(s)

FJ825759

UniProtKB/TrEMBL

A0A8C0M968, A0A8C0S2J0, C7T1J3, F6PNJ4

Related

ENSCAFP00845020678.1, ENSCAFT00845026230.1

Conserved Domains (1) summary

cd00190
Location:25 → 247

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

106321331..106325935

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038653533.1 → XP_038509461.1 kallikrein-14 isoform X1

UniProtKB/TrEMBL

A0A8C0M5K1

Conserved Domains (1) summary

cd00190
Location:25 → 161

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...