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ATP1B3 ATPase Na+/K+ transporting subunit beta 3 [ Homo sapiens (human) ]

Gene ID: 483, updated on 5-Jul-2020

Summary

Official Symbol
ATP1B3provided by HGNC
Official Full Name
ATPase Na+/K+ transporting subunit beta 3provided by HGNC
Primary source
HGNC:HGNC:806
See related
Ensembl:ENSG00000069849 MIM:601867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD298; ATPB-3
Summary
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 108.4), skin (RPKM 99.2) and 22 other tissues See more
Orthologs

Genomic context

See ATP1B3 in Genome Data Viewer
Location:
3q23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141876643..141926549)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141595424..141645382)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374134 Neighboring gene VISTA enhancer hs2041 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 25 Neighboring gene RNA, U6 small nuclear 509, pseudogene Neighboring gene transcription factor Dp-2 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene RNA, U6 small nuclear 425, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ29027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to cation-transporting ATPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sodium:potassium-exchanging ATPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular potassium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
sodium:potassium-exchanging ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-3
Names
ATPase, Na+/K+ transporting, beta 3 polypeptide
Na, K-ATPase beta-3 polypeptide
sodium pump subunit beta-3
sodium-potassium ATPase subunit beta 3 (non-catalytic)
sodium/potassium-dependent ATPase subunit beta-3
sodium/potassium-transporting ATPase beta-3 chain
NP_001670.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001679.4NP_001670.1  sodium/potassium-transporting ATPase subunit beta-3

    See identical proteins and their annotated locations for NP_001670.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AK131061, CN295803, DB307448
    Consensus CDS
    CCDS3121.1
    UniProtKB/Swiss-Prot
    P54709
    Related
    ENSP00000286371.3, ENST00000286371.8
    Conserved Domains (1) summary
    TIGR01107
    Location:1279
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    141876643..141926549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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