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NMBR neuromedin B receptor [ Homo sapiens (human) ]

Gene ID: 4829, updated on 24-Nov-2020

Summary

Official Symbol
NMBRprovided by HGNC
Official Full Name
neuromedin B receptorprovided by HGNC
Primary source
HGNC:HGNC:7843
See related
Ensembl:ENSG00000135577 MIM:162341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BB1; BB1R; NMB-R
Summary
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NMBR in Genome Data Viewer
Location:
6q24.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (142074484..142147122, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (142396745..142409936, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378031 Neighboring gene uncharacterized LOC107986654 Neighboring gene Sharpr-MPRA regulatory region 1984 Neighboring gene gap junction protein epsilon 1 Neighboring gene vesicle trafficking 1 Neighboring gene uncharacterized LOC105378032

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bombesin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
bombesin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuromedin-B receptor
Names
bombesin receptor 1
epididymis secretory sperm binding protein Li 185a
epididymis tissue protein Li 185a
neuromedin-B-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324307.2NP_001311236.1  neuromedin-B receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AL033522, AL589674, BX111967, DB462076, M73482
    UniProtKB/Swiss-Prot
    P28336
    Conserved Domains (1) summary
    pfam00001
    Location:3174
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001324308.2NP_001311237.1  neuromedin-B receptor isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AL033522, AL589674, BX111967, DB462076, M73482
    UniProtKB/Swiss-Prot
    P28336
    Conserved Domains (1) summary
    pfam00001
    Location:3174
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_002511.4NP_002502.2  neuromedin-B receptor isoform a

    See identical proteins and their annotated locations for NP_002502.2

    Status: REVIEWED

    Source sequence(s)
    AL033522, AL589674
    Consensus CDS
    CCDS5196.1
    UniProtKB/Swiss-Prot
    P28336
    Related
    ENSP00000258042.1, ENST00000258042.1
    Conserved Domains (1) summary
    pfam00001
    Location:60322
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    142074484..142147122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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