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Nmbr neuromedin B receptor [ Mus musculus (house mouse) ]

Gene ID: 18101, updated on 12-May-2024

Summary

Official Symbol
Nmbrprovided by MGI
Official Full Name
neuromedin B receptorprovided by MGI
Primary source
MGI:MGI:1100525
See related
Ensembl:ENSMUSG00000019865 AllianceGenome:MGI:1100525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; lung; lung epithelium; and lung mesenchyme. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 4.4), frontal lobe adult (RPKM 2.7) and 5 other tissues See more
Orthologs
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Genomic context

See Nmbr in Genome Data Viewer
Location:
10 A2; 10 5.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (14634894..14647202)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (14759356..14771458)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57851 Neighboring gene RIKEN cDNA 1700016L04 gene Neighboring gene gap junction protein, epsilon 1 Neighboring gene heat shock protein 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25840 Neighboring gene STARR-seq mESC enhancer starr_25841 Neighboring gene STARR-seq mESC enhancer starr_25843 Neighboring gene predicted gene, 23892 Neighboring gene centrosomal protein 55 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bombesin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuromedin-B receptor
Names
NMB-R
neuromedin-B-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008703.3NP_032729.1  neuromedin-B receptor

    See identical proteins and their annotated locations for NP_032729.1

    Status: VALIDATED

    Source sequence(s)
    AC111044
    Consensus CDS
    CCDS23707.1
    UniProtKB/Swiss-Prot
    O54799
    UniProtKB/TrEMBL
    Q0VEH1
    Related
    ENSMUSP00000020015.4, ENSMUST00000020015.10
    Conserved Domains (1) summary
    pfam00001
    Location:60322
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    14634894..14647202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244941.2XP_030100801.1  neuromedin-B receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:1642
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1273
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily