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NMB neuromedin B [ Homo sapiens (human) ]

Gene ID: 4828, updated on 24-Nov-2020

Summary

Official Symbol
NMBprovided by HGNC
Official Full Name
neuromedin Bprovided by HGNC
Primary source
HGNC:HGNC:7842
See related
Ensembl:ENSG00000197696 MIM:162340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Biased expression in fat (RPKM 21.3), brain (RPKM 11.2) and 5 other tissues See more
Orthologs

Genomic context

See NMB in Genome Data Viewer
Location:
15q25.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (84655132..84658611, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85198360..85201802, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SCAN domain containing 2 pseudogene Neighboring gene egl-9 family hypoxia inducible factor 1 pseudogene 1 Neighboring gene WD repeat domain 73 Neighboring gene SEC11 homolog A, signal peptidase complex subunit Neighboring gene zinc finger protein 592

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2277, MGC3936, MGC17211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity TAS
Traceable Author Statement
more info
PubMed 
neuromedin B receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuromedin-B
Names
Neuromedin-B-32
neuromedin-beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021077.4NP_066563.2  neuromedin-B isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_066563.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    BC007431, BC008603, BI858080
    Consensus CDS
    CCDS10332.1
    UniProtKB/Swiss-Prot
    P08949
    Related
    ENSP00000353664.3, ENST00000360476.8
    Conserved Domains (1) summary
    pfam02044
    Location:4760
    Bombesin; Bombesin-like peptide
  2. NM_205858.2NP_995580.1  neuromedin-B isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_995580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC007407, BI858080
    Consensus CDS
    CCDS42076.1
    UniProtKB/Swiss-Prot
    P08949
    Related
    ENSP00000378089.3, ENST00000394588.3
    Conserved Domains (1) summary
    pfam02044
    Location:4760
    Bombesin; Bombesin-like peptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    84655132..84658611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022239.1XP_016877728.1  neuromedin-B isoform X1

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