Nmb neuromedin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmbprovided by MGI
Official Full Name: neuromedin Bprovided by MGI
Primary source: MGI:MGI:1915289
See related: Ensembl:ENSMUSG00000025723 AllianceGenome:MGI:1915289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3110023K12Rik
Summary: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in satiety, reproduction and thermoregulation, as well as in stress, fear and other behavioral responses. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2016]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 2.5), thymus adult (RPKM 1.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 D3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80551975..80554810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80902227..80905062, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Title: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB.
Title: Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.
Study shows that itch deficits in mice lacking NMB or GRP are non-redundant and Nmb/Grp double KO (DKO) mice displayed additive deficits. Furthermore, both Nmb/Grp and Nmbr/Grpr DKO mice responded normally to a wide array of noxious stimuli. NMB and GRP may transmit discrete itch information and NMBR neurons are an integral part of neural circuits for itch in the spinal cord.
Title: Distinct roles of NMB and GRP in itch transmission.
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2.
Title: Neuromedin B and its receptor silencing suppresses osteoclast generation by modulating precursor proliferation via M-CSF/c-Fms/D-type cyclins.
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.
Title: Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice.
The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons.
Title: The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons.
The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway.
Title: Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice.
REsults describe the expression of neuromedin B in adipose tissue and its regulation by changes in energy balance.
Title: Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance.
lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I
Title: The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Homology

Homologs of the Nmb gene: The Nmb gene is conserved in human, chimpanzee, dog, cow, and rat.
Orthologs from Annotation Pipeline: 338 organisms have orthologs with human gene Nmb
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuromedin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables neuromedin B receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoclast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of respiratory gaseous exchange	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of itch	IDA Inferred from Direct Assay more info	PubMed
involved_in sneeze reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291280.1 → NP_001278209.1 neuromedin-B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001278209.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA671747, AC123744, CB058776

Consensus CDS

CCDS80742.1

UniProtKB/TrEMBL

D3Z621

Related

ENSMUSP00000113407.2, ENSMUST00000119428.2

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide
NM_026523.4 → NP_080799.1 neuromedin-B isoform 2 preproprotein

See identical proteins and their annotated locations for NP_080799.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC123744, CB058776

Consensus CDS

CCDS21400.1

UniProtKB/Swiss-Prot

Q9CR53

Related

ENSMUSP00000026817.5, ENSMUST00000026817.11

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide