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NINJ2 ninjurin 2 [ Homo sapiens (human) ]

Gene ID: 4815, updated on 7-Jun-2020

Summary

Official Symbol
NINJ2provided by HGNC
Official Full Name
ninjurin 2provided by HGNC
Primary source
HGNC:HGNC:7825
See related
Ensembl:ENSG00000171840 MIM:607297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]
Expression
Broad expression in lung (RPKM 12.3), bone marrow (RPKM 6.0) and 21 other tissues See more
Orthologs

Genomic context

See NINJ2 in Genome Data Viewer
Location:
12p13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (564296..663445, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (673462..772755, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4380 Neighboring gene coiled-coil domain containing 77 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 3 Neighboring gene uncharacterized LOC105369595 Neighboring gene RNA, U7 small nuclear 103 pseudogene Neighboring gene NINJ2 antisense RNA 1 Neighboring gene uncharacterized LOC101929432 Neighboring gene long intergenic non-protein coding RNA 2455 Neighboring gene CRISPRi-validated cis-regulatory element chr12.51 Neighboring gene RNA, U4atac small nuclear 16, pseudogene Neighboring gene WNK lysine deficient protein kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ninjurin-2
Names
nerve injury-induced protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294345.2NP_001281274.1  ninjurin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon which results in a different 5' UTR and causes translation initiation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AC006205, AF205633, BM128205, CB995632
    Consensus CDS
    CCDS73418.1
    UniProtKB/Swiss-Prot
    Q9NZG7
    UniProtKB/TrEMBL
    F8WBZ3
    Related
    ENSP00000380435.3, ENST00000397265.7
    Conserved Domains (1) summary
    pfam04923
    Location:18118
    Ninjurin; Ninjurin
  2. NM_001294346.2NP_001281275.1  ninjurin-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon which results in a different 5' UTR and causes translation initiation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 both encode the same isoform (3).
    Source sequence(s)
    AF205633, CD695373, R06312
    Consensus CDS
    CCDS76499.1
    UniProtKB/Swiss-Prot
    Q9NZG7
    UniProtKB/TrEMBL
    F5H3L1
    Related
    ENSP00000438831.1, ENST00000542920.1
    Conserved Domains (1) summary
    pfam04923
    Location:189
    Ninjurin; Ninjurin
  3. NM_001367996.1NP_001354925.1  ninjurin-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC006205, AC021054
  4. NM_016533.6NP_057617.3  ninjurin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC006205, AC021054, AF205633
    Consensus CDS
    CCDS8505.1
    Related
    ENSP00000307552.5, ENST00000305108.9

RNA

  1. NR_160428.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006205, AC021054

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    564296..663445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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